Results 51 to 60 of about 3,308,144 (197)

ADAMTS-1 is found predominantly in the nucleus.

, 2016
Immunofluorescence showing ADAMTS-1 localized in the nucleus, ADAMTS-4 and ADAMTS-5 are observed in cytoplasm in MCF-10A (A), MCF-7 (C) and MDA-MB-231 (D) cell lines.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Comparative assessment of changes ADAMTS-13/von Willebrand factor axis in singleton and bichorial biamniotic pregnancy

Акушерство, гинекология и репродукция
Aim: to compare changes in the ADAMTS-13 metalloproteinase/von Willebrand factor (vWF) axis in pregnant women with spontaneous or following in vitro fertilization (IVF) singleton and bichorial biamniotic pregnancies.Materials and Methods.
F. Е. Yagubova, V. O. Bitsadze, N. V. Samburova, J. Kh. Khizroeva, A. D. Makatsariya   +4 more
doaj   +1 more source

Von Willebrand factor:antigen and ADAMTS-13 level, but not soluble P-selectin, are risk factors for the first asymptomatic deep vein thrombosis in cancer patients undergoing chemotherapy

Thrombosis Journal, 2020
Background There is a high incidence of deep vein thrombosis (DVT) among cancer patients undergoing chemotherapy. Chemotherapy-induced vascular endothelial cell activation (VECA) is characterized by increased plasma levels of von Willebrand factor (vWF ...
Budi Setiawan, Cecilia Oktaria Permatadewi, Baringin de Samakto, Ashar Bugis, Ridho M. Naibaho, Eko Adhi Pangarsa, Damai Santosa, Catharina Suharti   +7 more
doaj   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the spondyloarthritis (SpA) spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

Platelet-derived VWF-cleaving metalloprotease ADAMTS-13 [PDF]

Journal of Thrombosis and Haemostasis, 2005
The adhesion ligand von Willebrand factor (VWF) is synthesized and stored in vascular endothelial cells and megakaryocytes/platelets. As in endothelial cells, platelet VWF also contains ultra-large (UL) multimers that are hyperactive in aggregating platelets.
L, Liu, H, Choi, A, Bernardo, A L, Bergeron, L, Nolasco, C, Ruan, J L, Moake, J-F, Dong   +7 more
openaire   +2 more sources

Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura [PDF]

, 2017
Key PointsFirst-in-human, phase 1 study, recombinant ADAMTS-13 was safe, nonimmunogenic, and tolerated in congenital thrombotic thrombocytopenic purpura.
Hibbard, Christopher, Johanna A. Kremer Hovinga, Scully, Marie, Fujimura, Yoshihiro, Michiko Kajiwara, Caterina Maggiore, Leah Martell, Martell, Leah, Karim Kentouche, Schneppenheim, Reinhard, Yoshihiro Fujimura, Kremer Hovinga, Johanna Anna, Rice, Lawrence, Doralt, Jennifer, Maggiore, Caterina, Ewenstein, Bruce, Knöbl, Paul, Marie Scully, Kajiwara, Michiko, Christopher Hibbard, Bruce Ewenstein, Jerzy Windyga, Paul Knöbl, Lawrence Rice, Reinhard Schneppenheim, Kentouche, Karim, Jennifer Doralt, Windyga, Jerzy   +27 more
core   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, EarlyView.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Antibody-mediated inhibition of von Willebrand factor (VWF) cleavage by ADAMTS-13 results in immune thrombotic thrombocytopenic purpura (iTTP).
Konstantine Halkidis, Chan Meng, Vikram G. Pillai, Madison Shay, Szumam Liu, X. Long Zheng   +5 more
doaj   +1 more source