Results 51 to 60 of about 4,617,382 (195)
ADAMTS-4 and ADAMTS-5 are found in the cytoplasm.
, 2016 Western blot containing cytoplasmic and nuclear fractions from MCF-10A (A), MCF-7 (B) and MDA-MB-231 (C) cells, probed for ADAMTS-4, ADAMTS-5, β-actin, histone and GAPDH.
Ruy G. Jaeger (618268) +4 more
core +1 more source
Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M. +5 more
core +1 more source
ADAMTS-13 deficiency: can it cause chronic renal failure?
, 2010 We describe a case of a 45-year-old woman with progressive chronic kidney disease (CKD), macrocytic anaemia without fragments or thrombocytopaenia, and thrombotic microangiopathy on renal biopsy.
Bramham, Kate +17 more
core +1 more source
Акушерство, гинекология и репродукция, 2023 Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova +11 more
doaj +1 more source
Advanced Science, EarlyView.TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu +12 more
wiley +1 more source
Conformational quiescence of ADAMTS‐13 prevents proteolytic promiscuity [PDF]
Journal of Thrombosis and Haemostasis, 2016 Essentials Recently, ADAMTS-13 has been shown to undergo substrate induced conformation activation. Conformational quiescence of ADAMTS-13 may serve to prevent off-target proteolysis in plasma. Conformationally active ADAMTS-13 variants are capable of proteolysing the Aα chain of fibrinogen. This should be considered as ADAMTS-13 variants are developed
South, K, Lane, DA, Freitas, MO
openaire +4 more sources
Research and Practice in Thrombosis and Haemostasis, 2019 Essentials Cancer is associated with increased risk of developing venous thrombosis. Cancer patients were studied for ADAMTS‐13 and VWF levels and occurrence of venous thrombosis.
Hanna L. Obermeier +8 more
doaj +1 more source
Medicina, 2019 Background and objectives: In children, acute infection is the most common cause of visits in the primary care or emergency department. In 2002, criteria for diagnostics of pediatric sepsis were published, and then revised in 2016 as “life ...
Linda Rautiainen +8 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede +11 more
wiley +1 more source
ADAMTS-1 is found predominantly in the nucleus.
, 2016 Immunofluorescence showing ADAMTS-1 localized in the nucleus, ADAMTS-4 and ADAMTS-5 are observed in cytoplasm in MCF-10A (A), MCF-7 (C) and MDA-MB-231 (D) cell lines.
Ruy G. Jaeger (618268) +4 more
core +1 more source