Results 41 to 50 of about 447 (133)

A comparative study of anti–ADAMTS-13 antibody dynamics in immune-mediated thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Thrombotic thrombocytopenic purpura, particularly its immune-mediated variant (iTTP), necessitates accurate diagnostic approaches for effective management.
Maria Rita Cozzi, Fabio Del Ben, Chiara Corso, Agostino Steffan   +3 more
doaj   +1 more source

Clinical relapse of immune‐mediated thrombotic thrombocytopenic purpura following COVID‐19 vaccination

Research and Practice in Thrombosis and Haemostasis, 2022
De novo and relapsed immune‐mediated thrombotic thrombocytopenic purpura (iTTP) have been documented to have occurred following severe acute respiratory syndrome coronavirus 2 (COVID‐19) vaccination.
William Deucher, Senthil Sukumar, Spero R. Cataland   +2 more
doaj   +1 more source

Clinical significance of measuring ADAMTS-13, its inhibitor and von Willebrand factor in obstetric and gynecological practice

Акушерство, гинекология и репродукция, 2021
ADAMTS-13 is a crucial metalloproteinase involved in liberating fragments of von Willebrand factor (vWF) into the plasma as well as regulating its activity by cleaving "ultra-large" multimers into smaller and less active counterparts.
K. N. Grigoreva, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, D. A. Ponomarev, K. Yu. Tsvetnova, D. A. Doronicheva, A. R. Mamaeva, K. V. Mekhedova, G. Rizzo, J.-C. Gris, I. Elalamy, A. D. Makatsariya   +12 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

von Willebrand factor cleaving protease (ADAMTS‐13) and ADAMTS‐13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura [PDF]

British Journal of Haematology, 2004
SummaryThe congenital or acquired deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS‐13 has been specifically associated with a diagnosis of thrombotic thrombocytopenic purpura (TTP), a microangiopathy characterized by the formation of occlusive platelet thrombi.
F. Peyvandi, S. Ferrari, S. Lavoretano, M. T. Canciani, P.M. Mannucci   +4 more
openaire   +3 more sources

Relationship Between Intraluminal Thrombus Volume and Circulating ADAMTS-13 Activity in Abdominal Aortic Aneurysms

EJVES Vascular Forum
Introduction: Abdominal aortic aneurysms (AAAs) with intraluminal thrombus (ILT) are suggested to be more prone to rupture than AAAs without. Prior studies indicate that the von Willebrand factor (vWf) plays a role in the formation of ILT since a ...
Qasam M. Ghulam, Jens P. Goetze, Nikolaj Eldrup, Jonas P. Eiberg   +3 more
doaj   +1 more source

Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions

Терапевтический архив, 2019
The article presents a brief description of a rare disease - thrombotic thrombocytopenic purpura (Moshkovits - disease), which is based on the deficiency of ADAMTS-13 metalloproteinase, leading to the development of thrombotic microangiopathy with the ...
A G Stolyar, P V Avdonin, I E Valamina, E S Stolyarevich   +3 more
doaj   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Platelet-derived VWF-cleaving metalloprotease ADAMTS-13 [PDF]

Journal of Thrombosis and Haemostasis, 2005
The adhesion ligand von Willebrand factor (VWF) is synthesized and stored in vascular endothelial cells and megakaryocytes/platelets. As in endothelial cells, platelet VWF also contains ultra-large (UL) multimers that are hyperactive in aggregating platelets.
L, Liu, H, Choi, A, Bernardo, A L, Bergeron, L, Nolasco, C, Ruan, J L, Moake, J-F, Dong   +7 more
openaire   +2 more sources

Functioning of the ADAMTS-13/vWF axis and its clinical significance

Акушерство, гинекология и репродукция, 2023
Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both in health and disease. ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and von Willebrand factor (vWF)
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, J.-C. Gris, A. E. Malikova, D. V. Blinov, V. I. Tsibizova, N. D. Degtyareva, S. V. Martirosyan, A. D. Makatsariya   +12 more
doaj   +1 more source