Results 41 to 50 of about 3,308,144 (197)
Conformational quiescence of ADAMTS‐13 prevents proteolytic promiscuity [PDF]
Journal of Thrombosis and Haemostasis, 2016 Essentials Recently, ADAMTS-13 has been shown to undergo substrate induced conformation activation. Conformational quiescence of ADAMTS-13 may serve to prevent off-target proteolysis in plasma. Conformationally active ADAMTS-13 variants are capable of proteolysing the Aα chain of fibrinogen. This should be considered as ADAMTS-13 variants are developed
South, K, Lane, DA, Freitas, MO
openaire +4 more sources
ADAMTS-13 proteolyzed by thrombin has reduced affinity for von Willebrand factor (VWF)
, 2011 (A) 6 n ADAMTS-13, 60 n thrombin-cleaved ADAMTS-13 (ADAMTS-13/FIIa) or 60 n thrombin-cleaved ADAMTS-13/6 n ADAMTS-13 (10:1 mix) was incubated with 10 n purified plasma-derived VWF in the presence of 1.5 urea and 5 m BaCl.
C K N K CHION (48919) +4 more
core +1 more source
Акушерство, гинекология и репродукция, 2023 Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova +11 more
doaj +1 more source
, 2008 Background: Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von Willebrand factor-cleaving protease (ADAMTS-13) activity.
Cohen, H. +7 more
core +1 more source
ADAMTS-13 deficiency: can it cause chronic renal failure?
, 2010 We describe a case of a 45-year-old woman with progressive chronic kidney disease (CKD), macrocytic anaemia without fragments or thrombocytopaenia, and thrombotic microangiopathy on renal biopsy.
Bramham, Kate +17 more
core +1 more source
Research and Practice in Thrombosis and Haemostasis, 2019 Essentials Cancer is associated with increased risk of developing venous thrombosis. Cancer patients were studied for ADAMTS‐13 and VWF levels and occurrence of venous thrombosis.
Hanna L. Obermeier +8 more
doaj +1 more source
ADAMTS-4 and ADAMTS-5 are found in the cytoplasm.
, 2016 Western blot containing cytoplasmic and nuclear fractions from MCF-10A (A), MCF-7 (B) and MDA-MB-231 (C) cells, probed for ADAMTS-4, ADAMTS-5, β-actin, histone and GAPDH.
Ruy G. Jaeger (618268) +4 more
core +1 more source
ADAMTS-1 is located in nucleolus.
, 2016 Immunofluorescence shows co-localization of ADAMTS-1 and nucleophosmin in MCF-10A, MCF-7 and MDA-MB-231 cell lines (A). MDA-MB-231 image used for colocalization analysis (B), with the white line used to generate the linescan plot (C).
Ruy G. Jaeger (618268) +4 more
core +1 more source
Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source