Results 41 to 50 of about 4,617,382 (195)

ADAMTS-13 and von Willebrand factor: a dynamic duo. [PDF]

J Thromb Haemost, 2018
von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must undergo conformational changes, both within its A1 domain and at the macromolecular level through A2 domain unfolding.
South K, Lane DA.
europepmc   +5 more sources

METALLOPROTEASE ADAMTS-13

Russian journal of hematology and transfusiology, 2019
Introduction. The signifi cance of ADAMTS-13 extends beyond its key role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP); there is evidence of a relationship between a decrease in the ADAMTS-13 activity and thrombotic events in acute myocardial infarction and ischemic stroke.Aim. To generalise available information on the structure and
A. V. Koloskov, A. A. Mangushlo
openaire   +2 more sources

ADAMTS proteases in cardiovascular physiology and disease [PDF]

Open Biology, 2020
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
doaj   +1 more source

Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection

, 2021
BACKGROUND: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by inhibitory and/or clearing anti-ADAMTS-13 (A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats, member 13) autoantibodies.
Mannik, Andres, Tellier, Edwige, Feys, Hendrik B., Kaplanski, Gilles, Vandenbulcke, Aline, Dekimpe, Charlotte, De Meyer, Simon F., Feys, Hendrik, Bonnez, Quintijn, Tersteeg, Claudia, Roose, Elien, Vanhoorelbeke, Karen, Kangro, Kadri, de Meyer, Simon   +13 more
core   +1 more source

Recombinant ADAMTS-13 Improves Survival of Mice Subjected to Endotoxemia [PDF]

, 2023
When stimulated by proinflammatory mediators, endothelial cells release ultra-large von Willebrand factor (ULVWF) multimers that are hyperactive in activating and aggregating platelets.
Huaizhu Wu, Trung Nguyen, Zhou, Zhou, Ma, Ruidong, Wu, Huaizhu, Liu, Li, Daniel Gao, Jingfei Dong, Zhou Zhou, Li Liu, Nguyen, Trung, Ruidong Ma, Gao, Daniel, Dong, Jingfei   +13 more
core   +1 more source

Plasmatic ADAMTS-13 metalloprotease and von Willebrand factor in children with cyanotic congenital heart disease

Brazilian Journal of Medical and Biological Research, 2013
Changes in plasma von Willebrand factor concentration (VWF:Ag) and ADAMTS-13 activity (the metalloprotease that cleaves VWF physiologically) have been reported in several cardiovascular disorders with prognostic implications.
R.P.S. Soares, S.P. Bydlowski, N.M. Nascimento, A.M. Thomaz, E.N.M. Bastos, A.A. Lopes   +5 more
doaj   +3 more sources

Thrombotic thrombocytopenic purpura as a rare cause of anemia with thrombocytopenia in childhood: report of 2 cases

The Turkish Journal of Pediatrics, 2019
Thrombotic thrombocytopenic purpura (TTP) is a rare multisystem disorder characterized by single or recurrent episodes of thrombocytopenia, microangiopathic hemolytic anemia and widespread microvascular thrombosis, which causes significant morbidity and
Oya Köker, Zeynep Yıldız Yıldırmak, Dildar Bahar Genç, Önder Kılıçaslan   +3 more
doaj   +1 more source

Expression and characterization of recombinant human ADAMTS-13 [PDF]

Seminars in Hematology, 2004
Thrombotic thrombocytopenic purpura (TTP) is a severe disease associated with unusually large, hemostatically hyperactive von Willebrand factor (VWF) and severe deficiency in ADAMTS-13, the protease responsible for the proteolytic degradation of VWF in plasma.
Barbara, Plaimauer, Friedrich, Scheiflinger   +1 more
openaire   +4 more sources

ADAMTS-13 proteolyzed by thrombin has reduced affinity for von Willebrand factor (VWF)

, 2011
(A) 6 n ADAMTS-13, 60 n thrombin-cleaved ADAMTS-13 (ADAMTS-13/FIIa) or 60 n thrombin-cleaved ADAMTS-13/6 n ADAMTS-13 (10:1 mix) was incubated with 10 n purified plasma-derived VWF in the presence of 1.5 urea and 5 m BaCl.
C K N K CHION (48919), S ZANARDELLI (48920), J T B CRAWLEY (48922), J K LAM (48918), D A LANE (48921)   +4 more
core   +1 more source

Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura

, 2008
Background: Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von Willebrand factor-cleaving protease (ADAMTS-13) activity.
Cohen, H., Machin, S.J., Crawley, J.T.B., Camilleri, R., Mackie, I.J., Skully, M., Lane, D.A., Starke, R.D.   +7 more
core   +1 more source