Assessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Marker [PDF]
Medicina, 2019 Background and objectives: In children, acute infection is the most common cause of visits in the primary care or emergency department. In 2002, criteria for diagnostics of pediatric sepsis were published, and then revised in 2016 as “life ...
Linda Rautiainen +8 more
doaj +2 more sources
von Willebrand factor cleaving protease (ADAMTS‐13) and ADAMTS‐13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura [PDF]
British Journal of Haematology, 2004 SummaryThe congenital or acquired deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS‐13 has been specifically associated with a diagnosis of thrombotic thrombocytopenic purpura (TTP), a microangiopathy characterized by the formation of occlusive platelet thrombi.
F. Peyvandi +4 more
openaire +4 more sources
Serum ADAMTS-13 Levels as an Indicator of Portal Vein Thrombosis [PDF]
Gastroenterology Research and Practice, 2018 Background. Coagulation disorders in patients with liver cirrhosis are a common clinical problem. Cirrhosis should be considered a state of impaired blood clotting or an imbalance of the whole coagulation system.
Tomasz Mikuła +5 more
doaj +2 more sources
Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction. [PDF]
J Thromb Haemost, 2022 Background Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown.
Fogarty H +23 more
europepmc +3 more sources
Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation
Акушерство, гинекология и репродукция, 2023 Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva +14 more
doaj +1 more source
The von Willebrand factor - ADAMTS-13 axis in malaria. [PDF]
Res Pract Thromb Haemost, 2022 Cerebral malaria (CM) continues to be associated with major morbidity and mortality, particularly in children aged
O'Donnell AS, Fazavana J, O'Donnell JS.
europepmc +6 more sources
Assay for ADAMTS-13 Activity with Flow Cytometric Readout. [PDF]
ACS Omega, 2022 A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13) is a metalloprotease that regulates the size of circulating von Willebrand factor (vWF) multimers. Severe lack of ADAMTS-13 activity [
Müller J +5 more
europepmc +4 more sources
The role of ADAMTS‐13 in the coagulopathy of sepsis [PDF]
Journal of Thrombosis and Haemostasis, 2018 The interaction between platelets and the vessel wall is mediated by various receptors and adhesive proteins, of which von Willebrand factor (VWF) is the most prominent. The multimeric size of VWF is an important determinant of a more intense platelet-vessel wall interaction, and is regulated by the VWF-cleaving protease ADAMTS-13.
Levi, M, Scully, M, Singer, M
openaire +3 more sources
DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
Pakistan Armed Forces Medical Journal, 2021 Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study.
Syed Owais Ali +5 more
doaj +1 more source
Recombinant ADAMTS 13 in thrombotic thrombocytopenic purpura. [PDF]
Oncoscience, 2017 Scully M, Hibbard C, Ewenstein B.
europepmc +3 more sources