Results 21 to 30 of about 4,617,382 (195)

A comparative study of anti–ADAMTS-13 antibody dynamics in immune-mediated thrombotic thrombocytopenic purpura [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Thrombotic thrombocytopenic purpura, particularly its immune-mediated variant (iTTP), necessitates accurate diagnostic approaches for effective management.
Maria Rita Cozzi, Fabio Del Ben, Chiara Corso, Agostino Steffan   +3 more
doaj   +2 more sources

ADAMTS-13 glycans and conformation-dependent activity. [PDF]

Journal of Thrombosis and Haemostasis, 2017
Background: ADAMTS-13 activity can be regulated by its conformation, whereby interactions between the C-terminal CUB domains and the spacer domain maintain ADAMTS-13 in a closed conformation.
Laffan, M.A., McKinnon, T.AJ., O'Brien, HER, M.A. Laffan, Henne, P., Doerr, A, K. Vanhoorelbeke, A.A. Nowak, Henne, P, Doerr, A., Nowak, AA, T.A.J. McKinnon, Nowak, A.A., O'Brien, H.ER., Vanhoorelbeke, K, Vanhoorelbeke, Karen, H.E.R. O'Brien, P. Henne, Laffan, MA, McKinnon, TAJ, A. Doerr   +20 more
core   +5 more sources

ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals [PDF]

Scientific Reports, 2023
This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis (Taenia multiceps).
Gungor Cagdas Dincel, Orhan Yavuz, Serkan Yildirim, Ebtesam M. Al-Olayan, Saeed El-Ashram   +4 more
doaj   +2 more sources

Monitoring ADAMTS-13 conformation in immune-mediated thrombotic thrombocytopenic purpura: toward personalized management [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy caused by an autoimmune-driven deficiency of ADAMTS-13.
Bérangère S. Joly, Elien Roose, Charlotte Dekimpe, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo   +5 more
doaj   +2 more sources

Relationship Between Intraluminal Thrombus Volume and Circulating ADAMTS-13 Activity in Abdominal Aortic Aneurysms [PDF]

EJVES Vascular Forum
Introduction: Abdominal aortic aneurysms (AAAs) with intraluminal thrombus (ILT) are suggested to be more prone to rupture than AAAs without. Prior studies indicate that the von Willebrand factor (vWf) plays a role in the formation of ILT since a ...
Qasam M. Ghulam, Jens P. Goetze, Nikolaj Eldrup, Jonas P. Eiberg   +3 more
doaj   +2 more sources

ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden [PDF]

Frontiers in Neurology, 2023
BackgroundThe identification of the underlying mechanism in ischemic stroke has important implications for secondary prevention. A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS-13) has antithrombotic properties and
Gerrit M. Grosse, Andrei Leotescu, Jan-Thorben Sieweke, Sonja Schneppenheim, Ulrich Budde, Nora L. Ziegler, Saskia Biber, Maria M. Gabriel, Johanna Ernst, Ramona Schuppner, Ralf Lichtinghagen, Udo Bavendiek, Julian Widder, Julian Widder, Karin Weissenborn   +14 more
doaj   +2 more sources

Low ADAMTS‐13 predicts adverse outcomes in hospitalized patients with suspected heparin‐induced thrombocytopenia [PDF]

Research and Practice in Thrombosis and Haemostasis, 2021
Background Heparin‐induced thrombocytopenia (HIT) is a life‐threatening thrombotic complication after heparin exposure. However, the role of ADAMTS‐13 and von Willebrand factor (VWF) in the disease process and outcomes of HIT is not known.
Meng Chan, Xinyang Zhao, X. Long Zheng
doaj   +2 more sources

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model [PDF]

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +2 more sources

Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation [PDF]

Clinical and Applied Thrombosis/Hemostasis
Thrombophilia in venous thromboembolism (VTE) is multifactorial. Von Willebrand factor (vWF) plays a major role in primary hemostasis. While elevated vWF levels are well documented in VTE, findings related to its cleaving protease (ADAMTS-13) are ...
Anwar Al-Awadhi PhD, Rajaa Marouf MBBch, DCP, FRCPath, Mehrez M. Jadaon MS, Mohammad M. Al-Awadhy MD   +3 more
doaj   +2 more sources

Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) related to ADAMTS-13 deficiency is associated with a maternal risk of death of 10% and a risk of fetal loss greater than 50% without treatment.
Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer   +7 more
doaj   +2 more sources