Results 31 to 40 of about 4,617,382 (195)
ADAMTS-13 assays in thrombotic thrombocytopenic purpura
Journal of Thrombosis and Haemostasis, 2010 ADAMTS-13, the thirteenth member of the ADAMTS (A Disintegrin And Metalloprotease with Thrombo-Spondin 1 repeats) family, is the plasma metalloprotease responsible for regulating the multimeric structure of VWF. In congenital or acquired deficiency it is
R. Palla +5 more
core +3 more sources
Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction. [PDF]
J Thromb Haemost, 2022 Background: Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown.
Fogarty H +23 more
europepmc +4 more sources
ADAMTS-13 in the Diagnosis and Management of Thrombotic Microangiopathies [PDF]
Rambam Maimonides Medical Journal, 2014 Thrombotic microangiopathies (TMAs) comprise a group of distinct disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis.
Galit Sarig
doaj +3 more sources
von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura [PDF]
British Journal of Haematology, 2004 The congenital or acquired deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS-13 has been specifically associated with a diagnosis of thrombotic thrombocytopenic purpura (TTP), a microangiopathy characterized by the formation of ...
S. Lavoretano +4 more
core +4 more sources
Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation
Акушерство, гинекология и репродукция, 2023 Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva +14 more
doaj +1 more source
The role of ADAMTS‐13 in the coagulopathy of sepsis [PDF]
Journal of Thrombosis and Haemostasis, 2018 The interaction between platelets and the vessel wall is mediated by various receptors and adhesive proteins, of which von Willebrand factor (VWF) is the most prominent. The multimeric size of VWF is an important determinant of a more intense platelet-vessel wall interaction, and is regulated by the VWF-cleaving protease ADAMTS-13.
Levi, M, Scully, M, Singer, M
openaire +3 more sources
DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
Pakistan Armed Forces Medical Journal, 2021 Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study.
Syed Owais Ali +5 more
doaj +1 more source
A rapid enzyme‐linked assay for ADAMTS‐13 [PDF]
Journal of Thrombosis and Haemostasis, 2006 A deficiency in the plasma metalloprotease ADAMTS-13 is associated with deposition of microvascular thrombi that cause thrombotic thrombocytopenic purpura. Current assays for ADAMTS-13 are technically complex and time-consuming. The objective of this study is to devise a rapid and sensitive assay for ADAMTS-13 activity in plasma and verify the site of ...
J-J, Wu +5 more
openaire +2 more sources
Saudi Journal of Kidney Diseases and Transplantation, 2018 Severe deficiency of ADAMTS-13 leads to thrombotic thrombocytopenic purpura. Few studies have reported reduced activity of ADAMTS-13 in patients with atypical and typical hemolytic uremic syndrome (HUS).
Naglaa A Khalifa +4 more
doaj +1 more source
Акушерство, гинекология и репродукция, 2023 Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk +10 more
doaj +1 more source