Results 31 to 40 of about 3,308,144 (197)
ADAMTS-13 and von Willebrand factor: a dynamic duo. [PDF]
J Thromb Haemost, 2018 von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must undergo conformational changes, both within its A1 domain and at the macromolecular level through A2 domain unfolding.
South K, Lane DA.
europepmc +5 more sources
A rapid enzyme‐linked assay for ADAMTS‐13 [PDF]
Journal of Thrombosis and Haemostasis, 2006 A deficiency in the plasma metalloprotease ADAMTS-13 is associated with deposition of microvascular thrombi that cause thrombotic thrombocytopenic purpura. Current assays for ADAMTS-13 are technically complex and time-consuming. The objective of this study is to devise a rapid and sensitive assay for ADAMTS-13 activity in plasma and verify the site of ...
J-J, Wu +5 more
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Акушерство, гинекология и репродукция, 2023 Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk +10 more
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Saudi Journal of Kidney Diseases and Transplantation, 2018 Severe deficiency of ADAMTS-13 leads to thrombotic thrombocytopenic purpura. Few studies have reported reduced activity of ADAMTS-13 in patients with atypical and typical hemolytic uremic syndrome (HUS).
Naglaa A Khalifa +4 more
doaj +1 more source
Russian journal of hematology and transfusiology, 2019 Introduction. The signifi cance of ADAMTS-13 extends beyond its key role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP); there is evidence of a relationship between a decrease in the ADAMTS-13 activity and thrombotic events in acute myocardial infarction and ischemic stroke.Aim. To generalise available information on the structure and
A. V. Koloskov, A. A. Mangushlo
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ADAMTS proteases in cardiovascular physiology and disease [PDF]
Open Biology, 2020 The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
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, 2021 BACKGROUND: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by inhibitory and/or clearing anti-ADAMTS-13 (A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats, member 13) autoantibodies.
Mannik, Andres +13 more
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Brazilian Journal of Medical and Biological Research, 2013 Changes in plasma von Willebrand factor concentration (VWF:Ag) and ADAMTS-13 activity (the metalloprotease that cleaves VWF physiologically) have been reported in several cardiovascular disorders with prognostic implications.
R.P.S. Soares +5 more
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Expression and characterization of recombinant human ADAMTS-13 [PDF]
Seminars in Hematology, 2004 Thrombotic thrombocytopenic purpura (TTP) is a severe disease associated with unusually large, hemostatically hyperactive von Willebrand factor (VWF) and severe deficiency in ADAMTS-13, the protease responsible for the proteolytic degradation of VWF in plasma.
Barbara, Plaimauer +1 more
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The Turkish Journal of Pediatrics, 2019 Thrombotic thrombocytopenic purpura (TTP) is a rare multisystem disorder characterized by single or recurrent episodes of thrombocytopenia, microangiopathic hemolytic anemia and widespread microvascular thrombosis, which causes significant morbidity and
Oya Köker +3 more
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