Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases
Angewandte Chemie, EarlyView.A proximity‐induced, mass‐encoded activity‐based protein profiling (ABPP) approach transfers a MALDI‐detectable α‐cyano‐4‐hydroxycinnamic acid (CHCA) tag directly to active proteases. This tag enables the direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification.
Lomane Berthy +20 more
wiley +2 more sources
Idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in a 17-year-old woman: a case report [PDF]
, 2011 Introduction Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome is a life-threatening condition with various etiopathogeneses. Without therapy approximately 90% of all patients die from the disease. Case presentation We report the case of a 17-
Arne Behlau +7 more
core +2 more sources
ADAMTS-13 and Von Willebrand factor in relation to platelet response during plasma exchange in thrombotic thrombocytopenic purpura: a clue for disease mechanism? [PDF]
, 2009 International ...
H. H. van Vliet +2 more
core +4 more sources
The Turkish Journal of Pediatrics, 2019 Thrombotic thrombocytopenic purpura (TTP) is a rare multisystem disorder characterized by single or recurrent episodes of thrombocytopenia, microangiopathic hemolytic anemia and widespread microvascular thrombosis, which causes significant morbidity and
Oya Köker +3 more
doaj +1 more source
Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis [PDF]
, 2013 Background: Vascular endothelial cells (ECs) express and release protein components of the complement pathways, as well as secreting and anchoring ultra-large von Willebrand factor (ULVWF) multimers in long string-like structures that initiate platelet ...
Moake, Joel, Turner, Nancy A.
core +2 more sources
Health technology assessment of pathogen reduction technologies applied to plasma for clinical use [PDF]
, 2016 Although existing clinical evidence shows that the transfusion of blood components is becoming increasingly safe, the risk of transmission of known and unknown pathogens, new pathogens or re-emerging pathogens still persists.
Berrino, Alexandra +18 more
core +1 more source
Акушерство, гинекология и репродукция, 2023 Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova +11 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2019 Essentials Cancer is associated with increased risk of developing venous thrombosis. Cancer patients were studied for ADAMTS‐13 and VWF levels and occurrence of venous thrombosis.
Hanna L. Obermeier +8 more
doaj +1 more source
Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon [PDF]
, 2006 To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs), and ADAM genes 8, 10, 12, and 17 in normal, painful, and ruptured ...
Alfredson +73 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell–cell interactions in FAI and hip OA.
Gulzada Kulzhanova +9 more
wiley +1 more source