Results 11 to 20 of about 447 (133)

ADAMTS-13 in the Diagnosis and Management of Thrombotic Microangiopathies [PDF]

Rambam Maimonides Medical Journal, 2014
Thrombotic microangiopathies (TMAs) comprise a group of distinct disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis.
Galit Sarig
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The role of ADAMTS‐13 in the coagulopathy of sepsis [PDF]

Journal of Thrombosis and Haemostasis, 2018
The interaction between platelets and the vessel wall is mediated by various receptors and adhesive proteins, of which von Willebrand factor (VWF) is the most prominent. The multimeric size of VWF is an important determinant of a more intense platelet-vessel wall interaction, and is regulated by the VWF-cleaving protease ADAMTS-13.
Levi, M, Scully, M, Singer, M
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Further characterization of ADAMTS‐13 inactivation by thrombin [PDF]

Journal of Thrombosis and Haemostasis, 2007
The multimeric size and platelet-tethering function of von Willebrand factor (VWF) are modulated by the plasma metalloprotease, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13). In vitro ADAMTS-13 is susceptible to proteolytic inactivation by thrombin.In this study, we aimed to characterize the inactivation ...
Lam, JK, Chion, CKNK, Zanardelli, S, Lane, DA, Crawley, JTB   +4 more
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ADAMTS‐13 glycans and conformation‐dependent activity [PDF]

Journal of Thrombosis and Haemostasis, 2017
Essentials The impact of N-linked glycosylation on ADAMTS-13 function has not been fully explored. The activity of glycan modified ADAMTS-13 was investigated under static and shear stress conditions. Terminal sialic acid on the metalloprotease domain glycans are important for ADAMTS-13 activity.
Nowak, AA, O'Brien, HER, Henne, P, Doerr, A, Vanhoorelbeke, K, Laffan, MA, McKinnon, TAJ   +6 more
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A rapid enzyme‐linked assay for ADAMTS‐13 [PDF]

Journal of Thrombosis and Haemostasis, 2006
A deficiency in the plasma metalloprotease ADAMTS-13 is associated with deposition of microvascular thrombi that cause thrombotic thrombocytopenic purpura. Current assays for ADAMTS-13 are technically complex and time-consuming. The objective of this study is to devise a rapid and sensitive assay for ADAMTS-13 activity in plasma and verify the site of ...
J-J, Wu, K, Fujikawa, E C, Lian, B A, McMullen, J D, Kulman, D W, Chung   +5 more
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METALLOPROTEASE ADAMTS-13

Russian journal of hematology and transfusiology, 2019
Introduction. The signifi cance of ADAMTS-13 extends beyond its key role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP); there is evidence of a relationship between a decrease in the ADAMTS-13 activity and thrombotic events in acute myocardial infarction and ischemic stroke.Aim. To generalise available information on the structure and
A. V. Koloskov, A. A. Mangushlo
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ADAMTS‐13 and bleeding phenotype in von Willebrand disease [PDF]

Research and Practice in Thrombosis and Haemostasis, 2020
The bleeding phenotype of von Willebrand disease (VWD) varies highly between patients and can only partly be explained by von Willebrand factor (VWF) parameters. By cleaving large VWF multimers into smaller, less active multimers, ADAMTS-13 is an important regulator of VWF activity.
Johan Boender, Angelique Nederlof, Karina Meijer, Evelien P. Mauser‐Bunschoten, Marjon H. Cnossen, Karin Fijnvandraat, Johanna G. van der Bom, Joke de Meris, Britta A.P. Laros‐van Gorkom, Karin P.M. van Galen, Jeroen Eikenboom, Moniek P.M de Maat, Frank W.G. Leebeek, M. Coppens, L. Nieuwenhuizen, R.Y.J. Tamminga, P.F. Ypma, F.J.W. Smiers, E. Beckers, P. Brons, F. Atiq   +20 more
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Plasmatic ADAMTS-13 metalloprotease and von Willebrand factor in children with cyanotic congenital heart disease

Brazilian Journal of Medical and Biological Research, 2013
Changes in plasma von Willebrand factor concentration (VWF:Ag) and ADAMTS-13 activity (the metalloprotease that cleaves VWF physiologically) have been reported in several cardiovascular disorders with prognostic implications.
R.P.S. Soares, S.P. Bydlowski, N.M. Nascimento, A.M. Thomaz, E.N.M. Bastos, A.A. Lopes   +5 more
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Expression and characterization of recombinant human ADAMTS-13 [PDF]

Seminars in Hematology, 2004
Thrombotic thrombocytopenic purpura (TTP) is a severe disease associated with unusually large, hemostatically hyperactive von Willebrand factor (VWF) and severe deficiency in ADAMTS-13, the protease responsible for the proteolytic degradation of VWF in plasma.
Barbara, Plaimauer, Friedrich, Scheiflinger   +1 more
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Thrombotic thrombocytopenic purpura as a rare cause of anemia with thrombocytopenia in childhood: report of 2 cases

The Turkish Journal of Pediatrics, 2019
Thrombotic thrombocytopenic purpura (TTP) is a rare multisystem disorder characterized by single or recurrent episodes of thrombocytopenia, microangiopathic hemolytic anemia and widespread microvascular thrombosis, which causes significant morbidity and
Oya Köker, Zeynep Yıldız Yıldırmak, Dildar Bahar Genç, Önder Kılıçaslan   +3 more
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