Results 11 to 20 of about 13,148 (179)

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model [PDF]

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +2 more sources

Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation [PDF]

Clinical and Applied Thrombosis/Hemostasis
Thrombophilia in venous thromboembolism (VTE) is multifactorial. Von Willebrand factor (vWF) plays a major role in primary hemostasis. While elevated vWF levels are well documented in VTE, findings related to its cleaving protease (ADAMTS-13) are ...
Anwar Al-Awadhi PhD, Rajaa Marouf MBBch, DCP, FRCPath, Mehrez M. Jadaon MS, Mohammad M. Al-Awadhy MD   +3 more
doaj   +2 more sources

Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) related to ADAMTS-13 deficiency is associated with a maternal risk of death of 10% and a risk of fetal loss greater than 50% without treatment.
Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer   +7 more
doaj   +2 more sources

Assessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Marker [PDF]

Medicina, 2019
Background and objectives: In children, acute infection is the most common cause of visits in the primary care or emergency department. In 2002, criteria for diagnostics of pediatric sepsis were published, and then revised in 2016 as “life ...
Linda Rautiainen, Anna Cirko, Jana Pavare, Reinis Balmaks, Ilze Grope, Irina Katirlo, Gita Gersone, Peteris Tretjakovs, Dace Gardovska   +8 more
doaj   +2 more sources

Serum ADAMTS-13 Levels as an Indicator of Portal Vein Thrombosis [PDF]

Gastroenterology Research and Practice, 2018
Background. Coagulation disorders in patients with liver cirrhosis are a common clinical problem. Cirrhosis should be considered a state of impaired blood clotting or an imbalance of the whole coagulation system.
Tomasz Mikuła, Joanna Kozłowska, Wojciech Stańczak, Mariusz Sapuła, Aleksandra Różyk, Alicja Wiercińska-Drapało   +5 more
doaj   +2 more sources

Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation

Акушерство, гинекология и репродукция, 2023
Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, V. I. Tsibizova, N. D. Degtyareva, A. V. Mulenkova, J.-C. Gris, M. V. Kvaratskheliia, E. Grandone, F. E. Yakubova, D. V. Blinov, A. D. Makatsariya   +14 more
doaj   +1 more source

Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent [PDF]

Korean Journal of Pediatrics, 2010
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by endothelial cell damage, resulting in microangiopathic hemolytic anemia, thrombocytopenia, and various degrees of neurological and renal impairment caused by ...
Eun Mi Yang, Dong Kyun Han, Hee Jo Baek, Young Ok Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang   +6 more
doaj   +1 more source

ADAMTS-13 gene expression in antiphospholipid syndrome

Turkish Journal of Hematology, 2011
OBJECTIVE: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and fetal mortality. Thrombotic microangiopathy (TMA) is an important histological finding in catastrophic APS (CAPS) and in APS patients with ...
Veysel Sabri Hançer, Reyhan Diz Küçükkaya, Ayşegül Topal Sarıkaya   +2 more
doaj   +3 more sources

DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY

Pakistan Armed Forces Medical Journal, 2021
Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study.
Syed Owais Ali, Chaudhry Altaf Hussain, Dawood Ahmad, Rafia Mahmood, Syeda Sarwat Fatima, Taqdees Fatima   +5 more
doaj   +1 more source

Von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture [PDF]

, 2009
Summary. Background: During sepsis, von Willebrand factor (VWF) is abundantly secreted; the main mechanism regulating its size involves specific proteolysis by the metalloprotease ADAMTS-13.
C. Dunois-Lardé, C.V. Denis, D. Baruch, D.G. Motto, G. Hill, I. Badirou, J.L. Diehl, N. Lerolle, P. Bruneval   +8 more
core   +4 more sources