Results 151 to 160 of about 4,756 (186)

Deciphering the Role of ADAMTS6 in the Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells. [PDF]

Int J Mol Sci
Odarenko KV, Matveeva AM, Stepanov GA, Zenkova MA, Markov AV.   +4 more
europepmc   +1 more source

HDAC inhibition upregulates the expression of angiostatic ADAMTS1 [PDF]

FEBS Letters, 2008
HDAC inhibitors are promising anticancer agents that induce cell cycle arrest and apoptosis. However, the role of HDACs in cancer progression, such as angiogenesis and metastasis, remains largely unexplored. Among various HDAC inhibitors, we demonstrate that TSA and SAHA upregulated the expression of angiostatic ADAMTS1 in A549 cells.
Ching-Chow Chen
exaly   +5 more sources

Over-expression of Adamts1 in mice alters bone mineral density

Journal of Bone and Mineral Metabolism, 2011
ADAMTS1, a secreted multifunctional metalloproteinase with disintegrin and thrombospondin motifs, is an early response gene of parathyroid hormone (PTH) in osteoblasts. Mice engineered to lack Adamts1 are smaller compared to wild-type (WT) mice and ADAMTS1 metalloproteinase activity has been shown to increase osteoblastic growth in collagen gels ...
Håkan Melhus, Thomas Lind, Mohammad Bohlooly-Y   +2 more
exaly   +4 more sources

The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study [PDF]

Laboratory Medicine, 2016
To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI.Thirty autopsied individuals were allocated into 2 groups, namely, a study group of ...
Ömer Akyol, Nursel Turkmen Inanir, Bulent Eren   +2 more
exaly   +9 more sources

The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways [PDF]

International Journal of Cancer, 2013
As it was first characterized in 1997, the ADAMTS (A Disintegrin and Metalloprotease with ThromboSpondin motifs) metalloprotease family has been associated with many physiological and pathological conditions. Of the 19 proteases belonging to this family, considerable attention has been devoted to the role of its first member ADAMTS1 in cancer. Elevated
Carmela Ricciardelli, Darryl Russell
exaly   +5 more sources

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ADAMTS1 as potential prognostic biomarker promotes malignant invasion of glioma

International Journal of Clinical Oncology, 2022
Glioma is the most common intracranial malignancy in adults with a high degree of malignancy and poor prognosis, which is largely attributed to the existence of glioma stem cells (GSCs). Previous evidence indicated that the matrix metalloproteinase ADAMTS1 was implicated in the process of tumor invasion, but the involvement of ADAMTS1 in glioma ...
Dongying Liu, Liu Dongying
exaly   +3 more sources

ADAMTS1 is regulated by interleukin-1β, not by hypoxia, in chondrosarcoma

Human Pathology, 2007
Angiogenesis is characteristic of cartilage tumors, not of normal cartilage tissue. In addition to our previous report on differential expression of proangiogenic vascular endothelial growth factor A (VEGF-A) in cartilage tumors, we analyzed the expression of a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), which has been ...
Albert Roessner, Med Saadettin Sel, Thomas Kalinski   +2 more
exaly   +3 more sources