Results 161 to 170 of about 4,756 (186)

ADAMTS1 is regulated by the EP4 receptor in the zebrafish ovary

General and Comparative Endocrinology, 2021
Prostaglandins (PGs) are a class of fatty-acid derived hormones that are essential in ovulation of teleosts, but their exact role remains unknown. One putative target of PGs in ovulation is regulation of the expression of members of the A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) family, which are implicated in follicular ...
Sheridan J C, Baker, Glen, Van Der Kraak
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ADAMTS1: A Matrix Metalloprotease with Angioinhibitory Properties

Annals of the New York Academy of Sciences, 2003
Abstract: Neovascularization is a hallmark of cancer progression. Suppression of the angiogenic response in tumors has been associated with inhibition and even regression of total tumor mass. Therefore, the derivation of synthetic or natural products that could interfere with proangiogenic signaling pathways can greatly impact cancer therapy.
M Luisa, Iruela-Arispe, Darren, Carpizo, Alfonso, Luque   +2 more
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The ADAMTS1 Gene Is Associated with Familial Mandibular Prognathism

Journal of Dental Research, 2015
Mandibular prognathism is a facial skeletal malocclusion. Until now, the genetic mechanism has been unclear. The goal of this study was to identify candidate genes or genomic regions directly associated with mandibular prognathism development, by employing whole genome sequencing.
X. Guan, Y. Song, J. Ott, Y. Zhang, C. Li, T. Xin, Z. Li, Y. Gan, J. Li, S. Zhou, Y. Zhou   +10 more
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Aberrant methylation of ADAMTS1 in non-small cell lung cancer

Cancer Genetics and Cytogenetics, 2008
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs) is an extracellular matrix metalloproteinase with protease activity and antiangiogenic activity. It has been suggested that ADAMTS1 plays an important role in tumor growth and metastasis.
Jin Eun Choi, Jae Yong Park, Sanghoon Jheon   +2 more
exaly   +3 more sources

Oxygen-dependent regulation of ADAMTS1 by VEGFA defines a novel VEGFA–HIF–ADAMTS1 axis in hepatocellular cancer

Tissue and Cell
ADAMTS1 is a matrix-associated protease involved in angiogenesis and tumor microenvironment remodeling, and its regulation under oxygen-limited conditions has not been fully elucidated. Vascular endothelial growth factor A (VEGFA) is one of the key regulators of angiogenesis and hypoxic signaling.
Feray, Kockar, Esra, Tokay, Nelin, Hacioglu, Kubilay, Gunerhan, Yasemin, Kalfa, Feyza Nur, Sav, Merve, Karaman, Meltem, Balaban, Kubra Zehra, Kalay   +8 more
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An anti-ADAMTS1 treatment relieved muscle dysfunction and fibrosis in dystrophic mice

Life Sciences, 2021
Duchenne Muscular Dystrophy (DMD) is caused by mutations in the dystrophin gene, accompanied by aberrant extracellular matrix synthesis and muscle damage. ADAMTS1 metalloproteinase was reported increased in dystrophin-deficient mdx mouse. The aim of this study was to explore the role of ADAMTS1 in muscle function, fibrosis and damage, and respiratory ...
Yan, Wang, Yanfeng, Xiao, Yanyan, Zheng, Le, Yang, Dong, Wang   +4 more
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Cx40, HAS2 und ADAMTS1

2012
Das Endothel, eine einschichtige Zelldecke, ist als innerste Auskleidung von Blutgefäßen direkt dem strömenden Blut ausgesetzt. Sein Funktionszustand wird neben anderen biochemischen und mechanischen Einflüssen durch Wandschubspannung moduliert. Diese ist je nach Lokalisation im Gefäßnetz unterschiedlich: an Prädilektionsstellen für Atherosklerose ...
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Identification of substrates of the extracellular protease ADAMTS1 by DIGE proteomic analysis

PROTEOMICS, 2006
Proteolytic modification of components of the extracellular milieu by metalloproteinases plays important roles in the regulation of multiple cellular and physiological processes and pathological conditions. ADAMTS1 is a secreted enzyme of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases, which is related ...
Francesc, Canals, Nuria, Colomé, Cristina, Ferrer, María del Carmen, Plaza-Calonge, Juan Carlos, Rodríguez-Manzaneque   +4 more
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Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation

Domestic Animal Endocrinology, 2013
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is a secreted protease. Through the regulation of extracellular matrix remodeling or developmental processes or both, ADAMTS1 is involved in several biological functions, including ovulation and embryo receptivity.
B, Mishra, K, Koshi, K, Kizaki, K, Ushizawa, T, Takahashi, M, Hosoe, T, Sato, A, Ito, K, Hashizume   +8 more
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ADAMTS1 Is Required for Ventral Abdominal Wall Closure

Journal of Histochemistry & Cytochemistry
ADAMTS1 (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 repeats) is a secreted metalloproteinase with a known role in extracellular matrix remodeling in cardiovascular development and female fertility. Because of conflicting report of embryonic lethality and survival in Adamts1
Gabriel Opoku, Kentaro Ikemura, Omer F. Hatipoglu, Takashi Ohtsuki, Ikumi Sato, Hibiki Taniguchi, Shino Sakamoto, Farhana Hasib, Shogo Watanabe, Timothy J. Mead, Suneel S. Apte, Satoshi Hirohata   +11 more
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