Results 41 to 50 of about 827,104 (288)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Indian Ocean Dipole (IOD) forecasts based on convolutional neural network with sea level pressure precursor

Environmental Research Letters
Forecasting the Indian Ocean Dipole (IOD) is crucial because of its significant impact on regional and global climates. While traditional dynamic and empirical models suffer from systematic errors due to nonlinear processes, convolutional neural networks
Yuqi Tao, Chunhua Qiu, Dongxiao Wang, Mingting Li, Guangli Zhang   +4 more
doaj   +1 more source

THE EFFECT OF LEARNING GOAL ORIENTATION ON SELF-PERCEIVED EMPLOYABILITY WITH CAREER ADAPTABILITY AS A MEDIATOR [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2019
Learning goal orientation is an individual characteristic that relatively stable and characterized by efforts to develop competence and perseverance in the face of obstacles (Dweck, 1986). A study shows that learning goal orientation is related to career
Faadhilah A.M.
doaj   +1 more source

Improving the adaptability of simulated evolutionary swarm robots in dynamically changing environments [PDF]

, 2014
One of the important challenges in the field of evolutionary robotics is the development of systems that can adapt to a changing environment. However, the ability to adapt to unknown and fluctuating environments is not straightforward.
Marchal, Kathleen, Van de Peer, Yves, Yao, Yao   +2 more
core   +4 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Objectivity, Proximity and Adaptability in Corporate Governance [PDF]

, 1999
Countries appear to differ considerably in the basic orientations of their corporate governance structures. We postulate the trade-off between objectivity and proximity as fundamental to the corporate governance debate. We stress the value of objectivity
Boot, Arnoud W. A., Macey, Jonathan R.
core  

Adaptivity and adaptation

Proceedings of the International Conference on Networked Learning, 2008
Within the iClass (Integrated Project n° 507922) and Elektra (Strep n°027986) European projects, the authors were requested to harness their pedagogical knowledge to the production of educational adaptive systems. The paper pinpoints and documents difficulties and limitations of this work as well as the possible fertility of such kind of ...
Dominique Verpoorten, L. Petit, J.-L. Castaigne, D. Leclercq   +3 more
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Impact of globalization and climate change on tourist destinations. A case study in Romania [PDF]

Romanian Journal of Regional Science
Globalization may increase development opportunities for tourist profiled destinations but is also a source of economic vulnerabilities if they lack adaptive capacity to context changes.
Daniela-Anca Dachin, Raluca-Corina Dawed
doaj   +1 more source

A model of downward abusive communication: exploring relationships between cognitive complexity, downward communicative adaptability, and downward abusive communication [PDF]

, 2013
Thesis (M.A.) University of Alaska Fairbanks, 2013A model was proposed to understand the antecedents of abusive supervision. Relationships were explored between cognitive complexity, downward communicative adaptability, and downward abusive communication.
Wallace, Elizabeth Adeline
core