Results 41 to 50 of about 840,971 (292)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Small and Medium-sized Enterprises’ Resilience to Socioeconomic Challenges in Emerging Economies: The Impact of Entrepreneurial Orientation on Organisational Ambidexterity [PDF]

SocioEconomic Challenges
In today’s rapidly evolving business landscape, small and medium-sized enterprises in emerging economies face mounting socioeconomic challenges that compel them to innovate while sustaining operational efficiency.
Medhat Abu Taleb, Passent Ibrahim Tantawi, Mohamed A. Ragheb, Dalia Amara   +3 more
doaj   +1 more source

Genetic Programming for Smart Phone Personalisation [PDF]

, 2014
Personalisation in smart phones requires adaptability to dynamic context based on user mobility, application usage and sensor inputs. Current personalisation approaches, which rely on static logic that is developed a priori, do not provide sufficient ...
Cotillon, Alban, Haak, Aiden, Jurdak, Raja, Valencia, Philip   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Indian Ocean Dipole (IOD) forecasts based on convolutional neural network with sea level pressure precursor

Environmental Research Letters
Forecasting the Indian Ocean Dipole (IOD) is crucial because of its significant impact on regional and global climates. While traditional dynamic and empirical models suffer from systematic errors due to nonlinear processes, convolutional neural networks
Yuqi Tao, Chunhua Qiu, Dongxiao Wang, Mingting Li, Guangli Zhang   +4 more
doaj   +1 more source

Objectivity, Proximity and Adaptability in Corporate Governance [PDF]

, 1999
Countries appear to differ considerably in the basic orientations of their corporate governance structures. We postulate the trade-off between objectivity and proximity as fundamental to the corporate governance debate. We stress the value of objectivity
Boot, Arnoud W. A., Macey, Jonathan R.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

THE EFFECT OF LEARNING GOAL ORIENTATION ON SELF-PERCEIVED EMPLOYABILITY WITH CAREER ADAPTABILITY AS A MEDIATOR [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2019
Learning goal orientation is an individual characteristic that relatively stable and characterized by efforts to develop competence and perseverance in the face of obstacles (Dweck, 1986). A study shows that learning goal orientation is related to career
Faadhilah A.M.
doaj   +1 more source

Adaptivity and adaptation

Proceedings of the International Conference on Networked Learning, 2008
Within the iClass (Integrated Project n° 507922) and Elektra (Strep n°027986) European projects, the authors were requested to harness their pedagogical knowledge to the production of educational adaptive systems. The paper pinpoints and documents difficulties and limitations of this work as well as the possible fertility of such kind of ...
Dominique Verpoorten, L. Petit, J.-L. Castaigne, D. Leclercq   +3 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source