Results 91 to 100 of about 1,206,348 (301)
Increasing autophagy does not affect neurogenic muscle atrophy
European Journal of Translational Myology, 2018 Physiological autophagy plays a crucial role in the regulation of muscle mass and metabolism, while the excessive induction or the inhibition of the autophagic flux contributes to the progression of several diseases.
Eva Pigna +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Insufficiency of Thyroid Hormone in Frog Metamorphosis and the Role of Glucocorticoids
Frontiers in Endocrinology, 2019 Thyroid hormone (TH) is the most important hormone in frog metamorphosis, a developmental process which will not occur in the absence of TH but can be induced precociously by exogenous TH.
Laurent M. Sachs, Daniel R. Buchholz
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Biological adaptations for cultural transmission?
Biology Letters, 2022 According to several interlinked and influential lines of argument, human minds have been shaped by natural selection so as to include biological adaptations with the evolved, naturally selected function to facilitate the transmission of cultural knowledge.
openaire +2 more sources
Contribution of sustainable agricultural management practices to reduce the impacts of extreme weather events in Tropical America [PDF]
, 2014 One of the most accessible adaptation strategies for climate change and extreme weather events for smallholder farmers consists in the implementation of sustainable management practices.
Avelino, Jacques +7 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
GeodermaPlant-soil interactions in terrestrial ecosystems profoundly shape the structure and function of belowground communities. Soil nematodes play a vital role in facilitating key belowground ecological processes, however, it remains poorly understood how ...
Chunyu Hou +7 more
doaj +1 more source
Probabilistic measures for biological adaptation and resilience
Physical Review EThis paper introduces a novel approach to quantifying ecological resilience in biological systems, particularly focusing on noisy systems responding to episodic disturbances with sudden adaptations. Incorporating concepts from non-equilibrium statistical mechanics, we propose a measure termed `ecological resilience through adaptation,' specifically ...
Ramirez, Jorge M. +3 more
openaire +3 more sources