Results 71 to 80 of about 4,492,371 (318)

Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis

Life Science Alliance
High-depth RNA sequencing reveals down-regulation of HP1α/CBX5 in monocytes of multiple sclerosis patients, associated with major transcriptomic changes and reduced activity of the Integrator complex. HP1α/CBX5 is an epigenetic regulator with a suspected
Yevheniia Porozhan, Mikkel Carstensen, Sandrine Thouroude, Mickael Costallat, Christophe Rachez, Eric Batsché, Thor Petersen, Tove Christensen, Christian Muchardt   +8 more
doaj   +1 more source

“We don’t want our clothes to smell smoke”: changing malaria control practices and opportunities for integrated community-based management in Baringo, Kenya

BMC Public Health, 2018
Background The decline in global malaria cases is attributed to intensified utilization of primary vector control interventions and artemisinin-based combination therapies (ACTs). These strategies are inadequate in many rural areas, thus adopting locally
Jacinter A. Amadi, Daniel O. Olago, George O. Ong’amo, Silas O. Oriaso, Isaac K. Nyamongo, Benson B. A. Estambale   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Decreasing psychological distance to climate adaptation through serious gaming: Minions of Disruptions

Climate Services
A gap between knowledge and adaptive action remains and psychological distancing has been proposed to explain peoples’ inaction. This presents a challenge to climate change communication and particularly to the conventional ways of providing scientific ...
Minja Sillanpää, Julia Eichhorn, Sirkku Juhola   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Thioredoxin 2 protects mice against experimental myocardial infarction

Redox Experimental Medicine
Experimental Myocardial infarction (MI) using ligation procedure induces cardiac dysfunction, high level of ROS, inflammation, apoptosis, fibrosis and cardiomyocyte (CM) loss. AAV overexpressing human Trx-2, specifically in CM mitochondria improves mouse
Tania Medali, Dominique Couchie, Nathalie Mougenot, Maria Mihoc, Olaf Bergmann, Wouter Derks, Celio X Santos, Bertrand Friguet, Mustapha Rouis   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Oxidative proteome alterations during skeletal muscle ageing

Redox Biology, 2015
Sarcopenia corresponds to the degenerative loss of skeletal muscle mass, quality, and strength associated with ageing and leads to a progressive impairment of mobility and quality of life.
Sofia Lourenço dos Santos, Martin A. Baraibar, Staffan Lundberg, Orvar Eeg-Olofsson, Lars Larsson, Bertrand Friguet   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1909

, 1910
Annual report of the Marine Biological Laboratory in Woods Hole. 1909.
Marine Biological Laboratory (Woods Hole MA)
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