Results 61 to 70 of about 1,206,348 (301)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Characterization of Scale Invariant Responses in Enzymatic Networks [PDF]

, 2012
An ubiquitous property of biological sensory systems is adaptation: a step increase in stimulus triggers an initial change in a biochemical or physiological response, followed by a more gradual relaxation toward a basal, pre-stimulus level.
A Asthagiri, A Grossman, A Kremling, A Ma'ayan, BA Mello, C Cohen-Saidon, C Widmann, CY Huang, D Angeli, D Lew, E Sontag, E Sontag, Eduardo D. Sontag, G Yao, GWO R Mesibov, H Chen, J Bijlsma, J Tsang, K Takeda, L Bleris, L Chang, L Goentoro, LA Ridnour, M Sulis, Maja Skataric, Mark S. Alber, MD Lazova, MP Mahaut-Smith, NA Shah, O Shoval, O Shoval, P Francois, P Iglesias, P Menè, R Nesher, RL Iman, S Donovan, S Mangan, S Marsigliante, S Paliwal, S Sasagawa, SM Block, T Nagashima, TM Yi, TS Shimizu, W Ma, YV Kalinin   +46 more
core   +5 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation

Stem Cell Research & Therapy
Background Beyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of heart failure in patients affected by desmin mutations remain unclear due in part, to the lack of ...
Yeranuhi Hovhannisyan, Zhenlin Li, Domitille Callon, Rodolphe Suspène, Vivien Batoumeni, Alexis Canette, Jocelyne Blanc, Hakim Hocini, Cécile Lefebvre, Nora El-Jahrani, Maria Kitsara, Aurore L’honoré, Ekaterini Kordeli, Paul Fornes, Jean-Paul Concordet, Gérard Tachdjian, Anne-Marie Rodriguez, Jean-Pierre Vartanian, Anthony Béhin, Karim Wahbi, Pierre Joanne, Onnik Agbulut   +21 more
doaj   +1 more source

Karyotypic evolution of the Medicago complex: sativa-caerulea-falcata inferred from comparative cytogenetic analysis

BMC Evolutionary Biology, 2017
Background Polyploidy plays an important role in the adaptation and speciation of plants. The alteration of karyotype is a significant event during polyploidy formation. The Medicago sativa complex includes both diploid (2n = 2× = 16) and tetraploid (2n =
Feng Yu, Haiqing Wang, Yanyan Zhao, Ruijuan Liu, Quanwen Dou, Jiangli Dong, Tao Wang   +6 more
doaj   +1 more source

Organisational Memetics?: Organisational Learning as a Selection Process [PDF]

, 1995
Companies are not only systems created and controlled by those who manage them but also self-organising entities that evolve through learning. Whereas an organism is a creation of natural replicators, genes, an organisation can be seen as a product of an
Price, Ilfryn
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

“We don’t want our clothes to smell smoke”: changing malaria control practices and opportunities for integrated community-based management in Baringo, Kenya

BMC Public Health, 2018
Background The decline in global malaria cases is attributed to intensified utilization of primary vector control interventions and artemisinin-based combination therapies (ACTs). These strategies are inadequate in many rural areas, thus adopting locally
Jacinter A. Amadi, Daniel O. Olago, George O. Ong’amo, Silas O. Oriaso, Isaac K. Nyamongo, Benson B. A. Estambale   +5 more
doaj   +1 more source

gcodeml: A Grid-enabled Tool for Detecting Positive Selection in Biological Evolution [PDF]

, 2012
One of the important questions in biological evolution is to know if certain changes along protein coding genes have contributed to the adaptation of species. This problem is known to be biologically complex and computationally very expensive.
Castella, Briséïs, Kuzniar, Arnold, Maffioletti, Sergio, Moretti, Sébastien, Murri, Riccardo, Robinson-Rechavi, Marc, Salamin, Nicolas, Stockinger, Heinz   +7 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source