Results 61 to 70 of about 434,212 (312)

Breathing life into climate change adaptation

, 2019
The exploration of evolutionary biology and biological adaptation can inform society's adaptation to climate change, particularly the mechanisms that bring about adaptability, such as phenotypic plasticity, epigenetics, and horizontal gene transfer ...
Luke Houghton, Stadler, Frank, Houghton, Luke, Frank Stadler   +3 more
core   +1 more source

3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

Bioactive Materials, 2022
The pathophysiology of dilated cardiomyopathy (DCM), one major cause of heart failure, is characterized by the dilation of the heart but remains poorly understood because of the lack of adequate in vitro models.
Marie Camman, Pierre Joanne, Onnik Agbulut, Christophe Hélary   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Impact of visual motion adaptation on neural responses to objects and its dependence on the temporal characteristics of optic flow

, 2011
Liang P, Kern R, Kurtz R, Egelhaaf M. Impact of visual motion adaptation on neural responses to objects and its dependence on the temporal characteristics of optic flow. Journal of Neurophysiology.
Egelhaaf, Martin ; https://orcid.org/, Kern, Roland ; https://orcid.org/, Kurtz, Rafael, Liang, Pei   +3 more
core   +1 more source

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation

Stem Cell Research & Therapy
Background Beyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of heart failure in patients affected by desmin mutations remain unclear due in part, to the lack of ...
Yeranuhi Hovhannisyan, Zhenlin Li, Domitille Callon, Rodolphe Suspène, Vivien Batoumeni, Alexis Canette, Jocelyne Blanc, Hakim Hocini, Cécile Lefebvre, Nora El-Jahrani, Maria Kitsara, Aurore L’honoré, Ekaterini Kordeli, Paul Fornes, Jean-Paul Concordet, Gérard Tachdjian, Anne-Marie Rodriguez, Jean-Pierre Vartanian, Anthony Béhin, Karim Wahbi, Pierre Joanne, Onnik Agbulut   +21 more
doaj   +1 more source

Is Storytelling a Biological Adaptation? [PDF]

, 2012
Verbal storytelling – in a sense broad enough to include all forms from casual conversation across oral folklore to written literature – seems to be a universal human activity and has thus been considered an evolutionary adaptation several times in the past few years.
openaire   +1 more source

An Adaptation of Bicgstab for Nonlinear Biological Systems [PDF]

, 2006
Here we propose a new adaptation of Van der Vorst’s BiCGStab to nonlinear systems, a method combining the iterative features of both sparse linear system solvers, such as BiCGStab, and of nonlinear systems, which in general are linearized by forming Jacobians, and whose resulting system usually involves the use of a linear solver.
Ezio Venturino, Peter R. Graves-Morris, Alessandra De Rossi   +2 more
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Karyotypic evolution of the Medicago complex: sativa-caerulea-falcata inferred from comparative cytogenetic analysis

BMC Evolutionary Biology, 2017
Background Polyploidy plays an important role in the adaptation and speciation of plants. The alteration of karyotype is a significant event during polyploidy formation. The Medicago sativa complex includes both diploid (2n = 2× = 16) and tetraploid (2n =
Feng Yu, Haiqing Wang, Yanyan Zhao, Ruijuan Liu, Quanwen Dou, Jiangli Dong, Tao Wang   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source