Results 81 to 90 of about 434,212 (312)
Stem Cell ResearchMyofibrillar myopathy (MFM) is a rare genetic disorder characterized by muscular dystrophy that is often associated with cardiac disease. This disease is caused by mutations in several genes, among them DES (encoding desmin) is the most frequently ...
Pierre Joanne +11 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Evolution in a changing environment [PDF]
, 2012 We propose a simple model for genetic adaptation to a changing environment, describing a fitness landscape characterized by two maxima. One is associated with "specialist" individuals that are adapted to the environment; this maximum moves over time as ...
Christiansen, Morten H. +17 more
core +1 more source
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
Life Science AllianceHigh-depth RNA sequencing reveals down-regulation of HP1α/CBX5 in monocytes of multiple sclerosis patients, associated with major transcriptomic changes and reduced activity of the Integrator complex. HP1α/CBX5 is an epigenetic regulator with a suspected
Yevheniia Porozhan +8 more
doaj +1 more source
Oxidative proteome alterations during skeletal muscle ageing
Redox Biology, 2015 Sarcopenia corresponds to the degenerative loss of skeletal muscle mass, quality, and strength associated with ageing and leads to a progressive impairment of mobility and quality of life.
Sofia Lourenço dos Santos +5 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Climate ServicesA gap between knowledge and adaptive action remains and psychological distancing has been proposed to explain peoples’ inaction. This presents a challenge to climate change communication and particularly to the conventional ways of providing scientific ...
Minja Sillanpää +2 more
doaj +1 more source
Evolutionary Applications, 2020 Twenty years of genetic studies of marine invaders have shown that successful invaders are often characterized by native and introduced populations displaying similar levels of genetic diversity.
Sabrina Le Cam +5 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Thioredoxin 2 protects mice against experimental myocardial infarction
Redox Experimental MedicineExperimental Myocardial infarction (MI) using ligation procedure induces cardiac dysfunction, high level of ROS, inflammation, apoptosis, fibrosis and cardiomyocyte (CM) loss. AAV overexpressing human Trx-2, specifically in CM mitochondria improves mouse
Tania Medali +8 more
doaj +1 more source