Results 131 to 140 of about 2,705,846 (305)

Editorial: Physiological Mini-Reviews, failure or success?

, 2022
The first number of “Physiological Mini-Reviews” was published in august 2005. After the first 20 issues, which were published both in the electronic and “on paper” version, we think that an initial assessment can be made. Physiological Mini-Reviews was
Physiological Mini-Reviews
core  

Myocardial Fibrosis in Athletes: Risk Marker or Physiological Adaptation?

Biomedicines
Endurance exercise is widely recognized for its cardiovascular benefits, including improved longevity and metabolic health. However, excessive endurance training may lead to adverse cardiac adaptations, such as myocardial fibrosis, detected via late ...
Vasiliki Katsi, Epameinondas Triantafyllou, Christos Fragoulis, Christos Vazaios, Spyridon Maragkoudakis, Alexandros Kasiakogias, Charalampos Vlachopoulos, Konstantinos P. Tsioufis   +7 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Adaptor of last resort? An economic perspective on the government’s role in adaptation to climate change [PDF]

, 2013
 Individuals and societies have always adapted to change, whether catastrophic or slow onset. Over the last two centuries, however, governments have significantly extended their role as ultimate social manager of risk.
Leo Dobes, Patrick Doupe, Frank Jotzo
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Investigating environmental heat exposure and its effects on maternal and fetal health in rural Northern Ghana (Physio-HeMAB Study): a study protocol for a cluster randomized trial

BMC Public Health
Background Climate change increases the frequency and intensity of heat events. Previous studies have established a correlation between heat exposure and adverse pregnancy outcomes, including preterm birth, stillbirth, and other maternal and fetal health
Rachel Sophie Zimmer, Edmund Yeboah, Lila Sax Dos Santos Gomes, Lena Fiebig, Antonio Torres Reyes, Alina Hermann, Aaron Kampim, Callistus Ireneous Nakpih, Annalena Horst, Michael Bergner, Marcus Riemer, Stephanie Wallwiener, Gilbert Abotisem Abiiro, James Akazili, Jan W. Kantelhardt, Martina Anna Maggioni, Manuela De Allegri, Daniel Azongo, Eva J. Kantelhardt   +18 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Climate Adaptation decision support Tool for Local Governments: CATLoG [PDF]

, 2013
The Intergovernmental Panel on Climate Change (IPCC), the globally-recognised reference body for climate-related research, describes warming of the climate system as ‘unequivocal’.
Supriya Mathew, Stefan Trueck, Ann Henderson-Sellers   +2 more
core  

We have liftoff: A discovery study to use artificial intelligence to identify adaptative profiles for future space missions

Physiological Reports
Long‐duration space missions will challenge astronauts' adaptive capacities. Interoception and heart rate variability (HRV), reflecting parasympathetic activity, are increasingly recognized as predictors of adaptation and health.
Barbara Le Roy, Damien Claverie, Lucas Sauvadet, Charles Martin‐Krumm, Marion Trousselard   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source