Results 121 to 130 of about 362,441 (313)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
The next stage of physiological anthropology
Journal of Physiological Anthropology, 2023 Akira Yasukouchi
doaj +1 more source
Physiological aspects of educational training adaptation of students
Acta Biomedica Scientifica, 2015 20 healthy male and female students of Artsakh State University aged 18-20 years have participated in an experiment to study the mechanisms of training adaptation.
H. G. Galstyan, S. M. Minasyan
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Diverse coping modes of maize in cool environment at early growth
BMC Plant BiologyBackground Maize cultivation has considerably expanded beyond its place of origin in Central America. The successful adaptation of maize to temperate climates can be achieved by selecting genotypes that demonstrate tolerance to low temperatures ...
Paweł Sowiński +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PHYSIOLOGICAL AND SOCIO-PEDAGOGICAL PROBLEMS OF ADAPTATION AND HEALTH
Вестник Кемеровского государственного университета, 2013 The materials presented summarize the theoretical and practical aspects of the research carried out by the scientific school «Physiological and socio-pedagogical problems of adaptation and health».
E. M. Kazin +7 more
doaj
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
The physiological and psychosocial adaptation of individuals with insulin-dependent diabetes and non-insulin-dependent diabetes [PDF]
, 1994 The purpose of this descriptive study was to identify, describe, and compare the physiological and psychosocial adaptation of individuals with insulin dependent diabetes and non-insulin dependent diabetes.
Wortell, Linda
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