Results 111 to 120 of about 2,705,846 (305)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The next stage of physiological anthropology
Journal of Physiological Anthropology, 2023 Akira Yasukouchi
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Physiological aspects of educational training adaptation of students
Acta Biomedica Scientifica, 2015 20 healthy male and female students of Artsakh State University aged 18-20 years have participated in an experiment to study the mechanisms of training adaptation.
H. G. Galstyan, S. M. Minasyan
doaj
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
A model of heart rate kinetics in response to exercise [PDF]
, 2008 We present a mathematical model, in the form of two coupled ordinary differential equations, for the heart rate kinetics in response to exercise. Our heart rate model is an adaptation of the model of oxygen uptake kinetics of Stirling: a physiological ...
Stirling, James +3 more
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PHYSIOLOGICAL AND SOCIO-PEDAGOGICAL PROBLEMS OF ADAPTATION AND HEALTH
Вестник Кемеровского государственного университета, 2013 The materials presented summarize the theoretical and practical aspects of the research carried out by the scientific school «Physiological and socio-pedagogical problems of adaptation and health».
E. M. Kazin +7 more
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Diverse coping modes of maize in cool environment at early growth
BMC Plant BiologyBackground Maize cultivation has considerably expanded beyond its place of origin in Central America. The successful adaptation of maize to temperate climates can be achieved by selecting genotypes that demonstrate tolerance to low temperatures ...
Paweł Sowiński +7 more
doaj +1 more source