Results 91 to 100 of about 358,354 (313)

Biophysical and Physiological Responses promoting Freeze Tolerance in Vertebrates

, 1994
Freeze tolerance, an overwintering adaptation of at least 10 species of ectothermic vertebrates, is promoted by integrated biophysical and physiological responses to ice forming within tissues.
JP Costanzo, RE, Lee
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adaptation to Hysterectomy: Design and Psychometric Properties Assessment of Hysterectomy Adaptation Scale

Iranian Journal of Nursing and Midwifery Research
Background: Adaptation to complications of hysterectomy is one of the topics of concern for women and health care providers. There is no instrument for evaluating adaptation to hysterectomy.
Fatemeh Goudarzi, Raheleh Babazadeh, Abbas Ebadi, Talat Khadivzadeh   +3 more
doaj   +1 more source

Adaptation in multisensory neurons

, 2008
The most studied region in the mammalian brain for multisensory integration is the deep superior colliculus (DSC). Neurophysiological experiments have revealed many response properties of DSC neurons, such as cross-modal enhancement (CME) and sub ...
Kuang, Xutao
core  

Accelerated QT adaptation following atropine-induced heart rate increase in LQT1 patients versus healthy controls : a sign of disturbed hysteresis

, 2022
Hysteresis, a ubiquitous regulatory phenomenon, is a salient feature of the adaptation of ventricular repolarization duration to heart rate (HR) change.
Vahedi, Farzad,, Jensen, Steen M.,, Bergfeldt, Lennart, Dahlberg, Pia,, Jensen, Steen M., Gransberg, Lennart, Dahlberg, Pia, Axelsson, Karl-Jonas, Axelsson, Karl-Jonas,, Bergfeldt, Lennart,, Vahedi, Farzad, Lundahl, Gunilla, Axelsson, Karl‐Jonas, Perkins, Rosie,, Gransberg, Lennart,, Lundahl, Gunilla,, Perkins, Rosie   +16 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Phenotyping for drought adaptation in wheat using physiological traits

Frontiers in Physiology, 2012
Wheat (Triticum spp) is one of the first domesticated food crops. It represents the first source of calories (after rice) and an important source of proteins in developing countries.
Philippe eMonneveux, Ruilian eJing, Satish eMisra   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Insect Behavior and Physiological Adaptation Mechanisms Under Starvation Stress

Frontiers in Physiology, 2019
Intermittent food shortages are commonly encountered in the wild. During winter or starvation stress, mammals often choose to hibernate while insects—in the form of eggs, mature larvae, pupae, or adults opt to enter diapause.
Dao-Wei Zhang, Zhong-Jiu Xiao, Bo-Ping Zeng, Kun Li, Yan-Long Tang   +4 more
doaj   +1 more source