Results 71 to 80 of about 358,354 (313)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Changes in Cortisol Awakening Response During 10 Days of High-Intensity Cycling Exercise

Life
Previous studies suggest that the cortisol awakening response (CAR) shows a biphasic pattern—either an increase or a blunting—in response to exercise involving overload, potentially reflecting physiological adaptation. However, its response to continuous
Yui Ogasawara, Takayuki Sugo, Hironobu Tsuchiya   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives [PDF]

فصلنامه ابن سینا, 2019
Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber.
Abolfazl Khademi, Zahra Jahanbakhsh, Mitra Yousefpour, Afsaneh Karami Juyani   +3 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cross Adaptation - Heat and Cold Adaptation to Improve Physiological and Cellular Responses to Hypoxia [PDF]

, 2017
To prepare for extremes of heat, cold or low partial pressures of O2, humans can undertake a period of acclimation or acclimatization to induce environment specific adaptations e.g.
Watt, Peter, Lee Taylor, Peter W. Watt, Gibson, Oliver, Watt, Peter; id_orcid, Taylor, Lee, Oliver R. Gibson, Neil S. Maxwell, Maxwell, Neil, Maxwell, Neil; id_orcid   +9 more
core   +3 more sources

Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice.

PLoS Genetics, 2019
Evolutionary adaptation to extreme environments often requires coordinated changes in multiple intersecting physiological pathways, but how such multi-trait adaptation occurs remains unresolved.
Rena M Schweizer, Jonathan P Velotta, Catherine M Ivy, Matthew R Jones, Sarah M Muir, Gideon S Bradburd, Jay F Storz, Graham R Scott, Zachary A Cheviron   +8 more
doaj   +1 more source

The CBL-CIPK network is involved in the physiological crosstalk between plant growth and stress adaptation

, 2022
Plants have evolved to deal with different stresses during plant growth, relying on complex interactions or crosstalk between multiple signalling pathways in plant cells. In this sophisticated regulatory network, Ca2+ transients in the cytosol ([Ca2+]cyt)
van der Linden, Gerard, Yuan, Guang, Xiang, Haiying, Mao, Jingjing, Liu, Haobao, Bai, Yuling, Wang, Qian, Mo, Zhijie, Visser, Richard G.F.   +8 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Physiological and biochemical changes in human spaceflights [PDF]

فصلنامه ابن سینا, 2017
At the moment, a variety of disasters including climate changes and meteorite fall threaten human society on the earth. So, scientists believe that it is important to explore viable alternative planets in the Solar System to ensure survival of the human ...
M Panjehpour, A Ghasemi
doaj