Results 81 to 90 of about 358,354 (313)

Avoid, attack or do both? Behavioral and physiological adaptations in natural enemies faced with novel hosts

BMC Evolutionary Biology, 2005
Background Confronted with well-defended, novel hosts, should an enemy invest in avoidance of these hosts (behavioral adaptation), neutralization of the defensive innovation (physiological adaptation) or both?
Brown Sam P, Vacher Corinne, Hochberg Michael E   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Study on Human Physiological Adaptation of Thermal Comfort Under Building Environment

, 2015
Aiming at the current situation in China with vast territory, diverse climate, and a big difference on thermal adaptation of the indoor thermal environment among the people in different regions, the paper analyzes the typical model research of thermal ...
Lin, Yufan, Zheng, Wuxing, Yang, Liu, Ren, Yimei   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Physiological aspects on altitudinal hypoxia adaptation

Acta Biológica Colombiana, 2002
This review describes the physiological changes found in people adapted to inter-mediate altitude hypoxi.
Joel Alberto Rojas Jaramillo
doaj  

Physiological and Genetic Basis of High-Altitude Indigenous Animals’ Adaptation to Hypoxic Environments

Animals
Adaptation is one of the fundamental characteristics of life activities; humans and animals inhabiting high altitudes are well adapted to hypobaric hypoxic environments, and studies on the mechanisms of this adaptation emerged a hundred years ago.
Pengfei Zhao, Shaobin Li, Zhaohua He, Xiong Ma   +3 more
doaj   +1 more source

Natural patterns of neural activity: how physiological mechanisms are orchestrated to cope with real life

, 2003
Kurtz R, Egelhaaf M. Natural patterns of neural activity: how physiological mechanisms are orchestrated to cope with real life. Molecular neurobiology. 2003;27(1):13-32.Physiological mechanisms of neuronal information processing have been shaped during ...
Egelhaaf, Martin ; https://orcid.org/, Kurtz, Rafael   +1 more
core   +1 more source

Design and conduct of 'Xtreme Alps' : a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude [PDF]

, 2013
The study of healthy human volunteers ascending to high altitude provides a robust model of the complex physiological interplay that emulates human adaptation to hypoxaemia in clinical conditions.
Meale, Paula M., Mythen, Monty, Mythen, Michael G., Cobb, Alexandra, Levett, Denny Z.H., Xtreme Alps Research Group, Grocott, Michael P.W., Gilbert-Kawai, Edward T., Feelisch, Martin, Cumpstey, Andrew, Martin, Daniel S., Fernandez, Bernadette O., Mitchell, Kay, Khosravi, Maryam   +13 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Creating a climate for food security: the business, people & landscapes in food production [PDF]

, 2013
Balancing human and environmental needs is urgent where food security and sustainability are under pressure from population increases and changing climates.
Nazrul Islam, Nasir Uddin, Angela Wardell-Johnson   +2 more
core