Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Supporting evidence-based adaptation decision-making in the Australian Capital Territory: a synthesis of climate change adaptation research [PDF]
, 2013 This research synthesis provides policy-makers and practitioners with an understanding of the building blocks for effective adaptation decision-making, as evidenced through the NCCARF research program.
Jennifer Cane
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Joining the dots: hydrology, freshwater ecosystem values and adaptation options [PDF]
, 2013 The objective of this research was to investigate and test the necessary steps in developing an adaptation planning framework for freshwater biodiversity.
Leon Barmuta, Peter Davies, Anne Watson
core
, 2011 In the present study, we analysed the training-intensity distribution and physiological adaptations over a 6-month period preceding an Ironman triathlon race.
Galloway, S D +5 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives [PDF]
فصلنامه ابن سینا, 2019 Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber.
Abolfazl Khademi +3 more
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Changes in Cortisol Awakening Response During 10 Days of High-Intensity Cycling Exercise
LifePrevious studies suggest that the cortisol awakening response (CAR) shows a biphasic pattern—either an increase or a blunting—in response to exercise involving overload, potentially reflecting physiological adaptation. However, its response to continuous
Yui Ogasawara +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source