Results 101 to 110 of about 2,568,811 (261)

Membrane lipid unsaturation as physiological adaptation to animal longevity

Frontiers in Physiology, 2013
The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems.
Alba eNaudí, Mariona eJové, Victòria eAyala, Manuel ePortero-Otin, Gustavo eBarja, Reinald ePamplona   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Climate Adaptation decision support Tool for Local Governments: CATLoG [PDF]

, 2013
The Intergovernmental Panel on Climate Change (IPCC), the globally-recognised reference body for climate-related research, describes warming of the climate system as ‘unequivocal’.
Supriya Mathew, Stefan Trueck, Ann Henderson-Sellers   +2 more
core  

Cultivar differences in heat tolerance of Oncidium orchids: physiological mechanisms and implications for breeding strategies

Frontiers in Plant Science
BackgroundOncidium orchids are a core economic genus in the global tropical ornamental flower industry, while sustained high temperature has become the key bottleneck restricting its commercial production.
Xiaoyan Luo, Xiaoyan Luo, Xiaoyan Luo, Xiaoyan Luo, Xiaoyu Hong, Xiaoyu Hong, Xiaoyu Hong, Xiaoyu Hong, Yuanhua Luo, Shuangshuang Yi, Xiaoyun Yu, Xiaoyun Yu, Xiaoyun Yu, Xiaoyun Yu, Chonghui Li, Chonghui Li, Chonghui Li, Chonghui Li, Yi Liao, Yi Liao, Yi Liao, Yi Liao, Mengjin Zhang, Shunjiao Lu, Shunjiao Lu, Shunjiao Lu, Shunjiao Lu   +26 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Climate change adaptation and the rental sector [PDF]

, 2013
The research employed an asset-based approach to understanding the capacities, assets and skills which tenants, landlords and housing managers bring to climate change adaptation. The project also took a pro-poor approach focusing on the adaptive capacity
Lesley Instone
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Rethinking disaster risk management and climate change adaptation [PDF]

, 2013
Australian governments face the twin challenges of dealing with extreme weather-related disasters (such as floods and bushfires) and adapting to the impacts of climate change.
Deanna Grant-Smith, Michael Howes, Kim Reis   +2 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source