Results 41 to 50 of about 7,062,162 (309)

Impact of Pre-adapted HIV Transmission

Nature Medicine, 2016
Human leukocyte antigen class I (HLA)-restricted CD8+ T lymphocyte (CTL) responses are crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of viral escape mutants remains unclear, as these variants can also reduce ...
J. Carlson, V. Du, N. Pfeifer, A. Bansal, Vincent Y. F. Tan, K. Power, C. Brumme, Anat Kreimer, Charles E. DeZiel, Nicoló Fusi, M. Schaefer, M. Brockman, J. Gilmour, M. Price, W. Kilembe, R. Haubrich, M. John, S. Mallal, R. Shapiro, J. Frater, P. Harrigan, T. Ndung’u, S. Allen, D. Heckerman, J. Sidney, Todd M. Allen, P. Goulder, Z. Brumme, E. Hunter, P. Goepfert   +29 more
semanticscholar   +1 more source

Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression

Nature Biotechnology, 2021
Methods for quantifying gene expression1 and chromatin accessibility2 in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been technically challenging.
Steven J. Wu, Scott N. Furlan, Anca B. Mihalas, Hatice S. Kaya-Okur, A. Feroze, Samuel N. Emerson, Ye Zheng, Kalee Carson, P. Cimino, C. Keene, J. Sarthy, R. Gottardo, K. Ahmad, S. Henikoff, Anoop P. Patel   +14 more
semanticscholar   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

BROA: An agent-based model to recommend relevant Learning Objects from Repository Federations adapted to learner profile

International Journal of Interactive Multimedia and Artificial Intelligence, 2013
Learning Objects (LOs) are distinguished from traditional educational resources for their easy and quickly availability through Web-based repositories, from which they are accessed through their metadata.
Paula Rodríguez, Valentina Tabares, Néstor Duque, Demetrio Ovalle, Rosa Vicari   +4 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study

The Journal of Headache and Pain
Background Previous research has shown an association between migraine and cardiovascular diseases (CVDs). However, limited studies have explored the progression of cardiovascular health (CVH) among individuals with migraine.
Jingbo Liang, Jia-Jun Ma, Harry Haoxiang Wang, Qingling Yang, Tongyu Ma, Qi Sun, Lin Yang, Yao Jie Xie   +7 more
doaj   +1 more source

The methylome of the model arbuscular mycorrhizal fungus, Rhizophagus irregularis, shares characteristics with early diverging fungi and Dikarya

Communications Biology, 2021
Anurag Chaturvedi et al. use long-read PacBio sequencing and LC-MS to profile 5mC and 6mA DNA methylation in the model arbuscular mycorrhizal fungus, Rhizophagus irregularis. Their results suggest that R.
Anurag Chaturvedi, Joaquim Cruz Corella, Chanz Robbins, Anita Loha, Laure Menin, Natalia Gasilova, Frédéric G. Masclaux, Soon-Jae Lee, Ian R. Sanders   +8 more
doaj   +1 more source