Results 61 to 70 of about 1,123,496 (269)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Infrared Small Target Detection via Multidirectional Local Gravitational Force and Level-Line Connectivity

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Infrared small target detection is significantly challenged by residual high-intensity background edges and a low signal-to-noise ratio. These issues hinder accurate target differentiation from the background and heighten the risk of false alarms.
Xuying Hao, Xianyuan Liu, Yujia Liu, Yijuan Qiu, Yunjing Zhang, Yi Cui, Tao Lei   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Accurate Light Field Depth Estimation Using Multi-Orientation Partial Angular Coherence

IEEE Access, 2019
Occlusion is a critical issue that affects the accuracy for light field depth estimation. In the presence of occlusions, the photo-consistency property is broken, making ambiguity near occlusion areas.
Zhenghua Guo, Junlong Wu, Xianfeng Chen, Shuai Ma, Licheng Zhu, Ping Yang, Bing Xu   +6 more
doaj   +1 more source

Knowledge Adaptation: Teaching to Adapt

CoRR, 2017
11 pages, 4 figures, 2 ...
Sebastian Ruder, Parsa Ghaffari, John G. Breslin   +2 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

SPDC-YOLO: An Efficient Small Target Detection Network Based on Improved YOLOv8 for Drone Aerial Image

Remote Sensing
Target detection in UAV images is of great significance in fields such as traffic safety, emergency rescue, and environmental monitoring. However, images captured by UAVs usually have multi-scale features, complex backgrounds, uneven illumination, and ...
Jingxin Bi, Keda Li, Xiangyue Zheng, Gang Zhang, Tao Lei   +4 more
doaj   +1 more source

Authoring of Adaptive and Adaptable Hypermedia [PDF]

J. Univers. Comput. Sci., 2008
Authoring of Adaptive and Adaptable ...
Cristea,Alexandra, Carro,Rosa
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source