Results 111 to 120 of about 5,183,374 (302)
Longitudinal follow-up of metformin treatment in Fragile X Syndrome
Frontiers in PsychologyIntroductionMetformin has been used as a targeted treatment to potentially improve cognition and slow the typical IQ decline that occurs during development among individuals with fragile X syndrome (FXS).
Panhaneath Seng +28 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Education Sciences(1) Deficits in adaptive behavior significantly hinder individuals with intellectual disabilities from performing essential daily tasks and participating in community life.
Pei Zhou, Zehui Zhan
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Development of the Texas adaptive behavior scale
, 1983 The purpose of this research was to construct an adaptive behavior scale for use with female prison inmates. The scale was used in the evaluation of adaptive behavior levels of fifty randomly chosen, female inmates within the Texas Department of ...
Summers, Vicki M.,1958-
core +3 more sources
Frontiers in PsychologyObjectiveVisual impairment (VI) affects millions of children worldwide and may influence neurodevelopmental processes beyond sensory functioning. Although cross-modal plasticity has been proposed as a compensatory mechanism, the extent to which VI ...
Kemily Correia +12 more
doaj +1 more source
, 2016 Robots inhabiting human environments need to act in relation to their own experience and embodiment as well as to social and emotional aspects. Robots that learn, act upon and incorporate their own experience and perception of others’ emotions into their
Barakova, Emilia +3 more
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringINTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS.
Emily K. Schworer +22 more
doaj +1 more source