Results 91 to 100 of about 5,183,374 (302)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Adaptive Rationality, Adaptive Behavior and Institutions [PDF]

, 2015
The economic literature focused on understanding decision-making and choice processes reveals a vast collection of approaches to human rationality. Theorists’ attention has moved from absolutely rational, utility-maximizing individuals to boundedly ...
Volchik Vyacheslav, V., Filonenko Yulia, V., Krivosheeva-Medyantseva Daria, D.   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Swimming Energy Economy in Bottlenose Dolphins Under Variable Drag Loading

Frontiers in Marine Science, 2018
Instrumenting animals with tags contributes additional resistive forces (weight, buoyancy, lift, and drag) that may result in increased energetic costs; however, additional metabolic expense can be moderated by adjusting behavior to maintain power output.
Julie M. van der Hoop, Julie M. van der Hoop, Andreas Fahlman, K. Alex Shorter, Joaquin Gabaldon, Julie Rocho-Levine, Victor Petrov, Michael J. Moore   +7 more
doaj   +1 more source

Modelling and analyzing adaptive self-assembling strategies with Maude [PDF]

Building adaptive systems with predictable emergent behavior is a challenging task and it is becoming a critical need. The research community has accepted the challenge by introducing approaches of various nature: from software architectures, to ...
Gadducci, Fabio, Lluch-Lafuente, Alberto, Bruni, Roberto, Corradini, Andrea, Vandin, Andrea   +4 more
core  

Movement models from sports provide representative task constraints for studying adaptive behavior in human movement systems

, 2006
Researchers studying adaptive behavior in human movement systems have traditionally employed simplified, laboratory-based movement models in an effort to conserve experimental rigor.
Hristovski, R, Araujo, D, Hristovski, Robert, Renshaw, I, Davids, Keith, Davids, K, Button, C, Button, Chris, Renshaw, Ian, Davids, Keith W., Araujo, Duarte   +10 more
core   +1 more source

Survey of data mining approaches to user modeling for adaptive hypermedia [PDF]

, 2006
The ability of an adaptive hypermedia system to create tailored environments depends mainly on the amount and accuracy of information stored in each user model.
Liu, X, E. Frias-Martinez, Chen, SY, Frias-Martinez, E, S.Y. Chen, X. Liu   +5 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

On Cognition as Dynamical Coupling : An Analysis of Behavioral Attractor Dynamics

, 2008
The interaction of brain, body, and environment can result incomplex behavior with rich dynamics, even for relatively simpleagents. Such dynamics are, however, often difficult to analyze.In this article, we explore the case of a simple simulated ...
Herrera, Carlos, Montebelli, Alberto, Herrera, Carlos,, Ziemke, Tom, Montebelli, Alberto,, Ziemke, Tom,   +5 more
core   +1 more source