Results 91 to 100 of about 1,002,977 (299)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Rethinking the Galapagos Islands as a Complex Social-Ecological System: Implications for Conservation and Management

Ecology and Society, 2008
The Galapagos Islands are among the most renowned natural sites in the world. Unlike other oceanic archipelagos, the ecological and evolutionary processes characteristic of Galapagos have been minimally affected by human activities, and the archipelago ...
José A. González, Carlos Montes, José Rodríguez, Washington Tapia   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Navigating the adaptive cycle: an approach to managing the resilience of social systems

Ecology and Society, 2015
The concept of resilience continues to crescendo since the 1990s, touching on multiple fields with multiple interpretations and uses. Here, we start from its origins in systems ecology, framing the resilience concept explicitly in the adaptive cycle with
Brian D. Fath, Carly A. Dean, Harald Katzmair   +2 more
doaj   +1 more source

Studies of Thermally Unstable Accretion Disks around Black Holes with Adaptive Pseudo-Spectral Domain Decomposition Method I. Limit-Cycle Behavior in the Case of Moderate Viscosity

, 2007
We present a numerical method for spatially 1.5-dimensional and time-dependent studies of accretion disks around black holes, that is originated from a combination of the standard pseudo-spectral method and the adaptive domain decomposition method ...
Honma F., Ju‐Fu Lu, Kawata A., Li Xue, Mayer M., Papaloizou J. C. B., Shakura N. I., Shuang‐Liang Li, Szuszkiewicz E.   +8 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Resilience Measurement and Evolution Characteristics of Resource-Based Cities in Heilongjiang Province Based on Adaptive Cycle Framework from 2010 to 2019

Fengjing Yuanlin
ObjectiveResource-based cities in Heilongjiang Province have encountered a series of challenges during their transformation, including resource depletion, industrial decline, environmental pollution, and population outflow.
Zhuolin TAN, Ming LU, Wei DONG, Yu DONG
doaj   +1 more source

Resilience, Adaptive Capacity, and the "Lock-in Trap" of the Western Australian Agricultural Region

Ecology and Society, 2004
Using the Western Australian (WA) agricultural region as an example of a large-scale social-ecological system (SES), this paper applies a framework based on resilience theory to examine the region's resilience and capacity for change and renewal. Despite
Helen E. Allison, Richard J. Hobbs
doaj   +1 more source