Results 71 to 80 of about 1,002,977 (299)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Comparative Resilience in Five North Pacific Regional Salmon Fisheries

open access: yesEcology and Society, 2010
Over the past century, regional fisheries for Pacific salmon (Oncorhynchus spp.) have been managed primarily for their provisioning function, not for ecological support and cultural significance. We examine the resilience of the regional salmon fisheries
Xanthippe Augerot, Courtland L. Smith
doaj   +1 more source

Measuring the Evolution of Urban Resilience Based on the Exposure–Connectedness–Potential (ECP) Approach: A Case Study of Shenyang City, China

open access: yesLand, 2021
Resilience is a new path to express and enhance urban sustainability. Cities suffer from natural shocks and human-made disturbances due to rapid urbanization and global climate change.
Xinghua Feng   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Soil cultures - the adaptive cycle of agrarian soil use in Central Europe: an interdisciplinary study using soil scientific and archaeological research

open access: yesEcology and Society, 2017
Today's global challenges (e.g., food security) are not unprecedented in human history. Starting with the Neolithic transition, the agricultural sector and society underwent several cultural and technological changes and endured natural challenges. These
Sandra Teuber   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Resilience, Panarchy, and World-Systems Analysis

open access: yesEcology and Society, 2007
The paper compares two ambitious conceptual structures. The first is the understanding of social-ecological systems developed around the term "resilience," and more recently the term "panarchy," in the work of Holling, Gunderson, and others.
Nicholas M. Gotts
doaj   +1 more source

Cycle-Consistent Domain Adaptive Faster RCNN [PDF]

open access: yesIEEE Access, 2019
Traditional object detection methods always assume both of the training and test data follow the same distribution, but this cannot always be guaranteed in the real world. Domain adaptive methods are proposed to handle this situation. However, existing methods generally ignore the semantic alignment at feature level when they try to align data ...
Dan Zhang   +5 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

An Indicator Framework for Assessing Agroecosystem Resilience

open access: yesEcology and Society, 2012
Taking departure in the theory of resilience in social-ecological systems, we present an analysis and discussion of how resilience theory can be applied to agroecosystems.
Joshua F. Cabell, Myles Oelofse
doaj   +1 more source

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