Results 61 to 70 of about 2,982,181 (249)

A spiral model for adding automatic, adaptive authoring to adaptive hypermedia [PDF]

open access: yes, 2008
At present a large amount of research exists into the design and implementation of adaptive systems. However, not many target the complex task of authoring in such systems, or their evaluation.
Cristea, Alexandra   +5 more
core   +1 more source

Assessing an Adaptive Cycle in a Social System under External Pressure to Change: the Importance of Intergroup Relations in Recreational Fisheries Governance

open access: yesEcology and Society, 2011
The adaptive cycle constitutes a heuristic originally used to interpret the dynamics of complex ecosystems in response to disturbance and change. It is assumed that socially constructed governance systems go through similar phases (K, Ω [omega], α [alpha]
Katrin Daedlow   +2 more
doaj   +1 more source

Advanced In-cycle and Cycle-to Cycle On-line Adaptive Control for Thermoforming of Large Thermoplastic Sheets [PDF]

open access: yesSAE Technical Paper Series, 2005
<div class="htmlview paragraph">This paper presents a control system for the thermoforming of large sheets. The system has three main purposes: Its primary purpose is for cycle-to-cycle control of the sheet temperature map as predicted by the thermoforming simulation.
Girard, Patrick   +3 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Process-Variation-Adaptive Network-on-Chip with Variable-Cycle Routers and Variable-Cycle Pipeline Adaptive Routing [PDF]

open access: yesIEICE Transactions on Electronics, 2012
As process technology is scaled down, a typical system on a chip (SoC) becomes denser. In scaled process technology, process variation becomes greater and increasingly affects the SoC circuits. Moreover, the process variation strongly affects network-on-chips (NoCs) that have a synchronous network across the chip.
Yohei Nakata   +2 more
openaire   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

"Adaptive response" - some underlying mechanisms and open questions [PDF]

open access: yes, 2008
Organisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One of them is induced radioresistance
Stephka G. Chankova   +5 more
core   +1 more source

Fit in the Body: Matching Embodied Cognition with Social-Ecological Systems

open access: yesEcology and Society, 2012
Analysis of fit has focused on the macrolevel fit between social institutions and ecosystems, and bypassed the microlevel fit between individual cognition and its socio-material environment.
Janne I. Hukkinen
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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