Results 81 to 90 of about 331,693 (264)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Contribution to the UN Post-2015 Development Agenda Based on the Concept of Resilience
Problemy Ekorozwoju, 2015 The authors of this paper suggest applying the concept of resilience in the process of setting up Sustainable Development Goals (SDGs) to be implemented in the United Nations Post-2015 Development Agenda.
Jürg Bloesch +8 more
doaj
Discovering Resilient Pathways for South African Water Management: Two Frameworks for a Vision
Ecology and Society, 2008 Factors that constitute resilience can themselves change over time in social-ecological systems. This poses a major challenge for understanding resilience and suggests greater investigation is needed of how social-ecological systems evolve through time ...
Erin L. Bohensky
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Navigating the adaptive cycle: an approach to managing the resilience of social systems
Ecology and Society, 2015 The concept of resilience continues to crescendo since the 1990s, touching on multiple fields with multiple interpretations and uses. Here, we start from its origins in systems ecology, framing the resilience concept explicitly in the adaptive cycle with
Brian D. Fath +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Resilience, Adaptive Capacity, and the "Lock-in Trap" of the Western Australian Agricultural Region
Ecology and Society, 2004 Using the Western Australian (WA) agricultural region as an example of a large-scale social-ecological system (SES), this paper applies a framework based on resilience theory to examine the region's resilience and capacity for change and renewal. Despite
Helen E. Allison, Richard J. Hobbs
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
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