Results 101 to 110 of about 1,002,977 (299)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ecology and Society, 2011 The adaptive cycle constitutes a heuristic originally used to interpret the dynamics of complex ecosystems in response to disturbance and change. It is assumed that socially constructed governance systems go through similar phases (K, Ω [omega], α [alpha]
Katrin Daedlow +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
When did the 2001 recession really start? [PDF]
The paper develops a non-parametric, non-stationary framework for business-cycle dating based on an innovative statistical methodology known as Adaptive Weights Smoothing (AWS).
Catalin Starica +2 more
core +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
THE CONCEPT OF RESILIENCE FROM A SUSTAINABLE DEVELOPMENT PERSPECTIVE [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2018 The resilience concept raises several conceptual problems, due to its multiple features. Once clarified the meaning of resilience concerning the science context, its paradigm reveals interdisciplinary nuances, which allow analysis of multiple phenomena
ANDREEA CONSTANTINESCU, SIMONA FRONE
doaj
Conceptualising Cluster Evolution: Beyond the Life-Cycle Model? [PDF]
Although the literature on the evolution of industrial clusters is not vast, a preferred approach has already become evident, based around the idea of a cluster 'life-cycle'. This approach has several limitations.
Peter Sunley, Ron Martin
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Fit in the Body: Matching Embodied Cognition with Social-Ecological Systems
Ecology and Society, 2012 Analysis of fit has focused on the macrolevel fit between social institutions and ecosystems, and bypassed the microlevel fit between individual cognition and its socio-material environment.
Janne I. Hukkinen
doaj +1 more source
Taming Uncertainty in the Assurance Process of Self-Adaptive Systems: a Goal-Oriented Approach
, 2019 Goals are first-class entities in a self-adaptive system (SAS) as they guide the self-adaptation. A SAS often operates in dynamic and partially unknown environments, which cause uncertainty that the SAS has to address to achieve its goals.
Caldas, Ricardo Diniz +4 more
core +1 more source