Results 111 to 120 of about 5,366,983 (311)
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Adaptive Estimation for Epidemic Renewal and Phylogenetic Skyline Models. [PDF]
Syst Biol, 2020 Parag KV, Donnelly CA.
europepmc +1 more source
Efficient Estimation in Semiparametric GARCH Models
It is well-known that financial data sets exhibit conditional heteroskedasticity.GARCH type models are often used to model this phenomenon. Since the distribution of the rescaled innovations is generally far from a normal distribution, a semiparametric ...
Klaassen, C.A.J., Drost, F.C.
core
Pointwise adaptive estimation for quantile regression [PDF]
A nonparametric procedure for quantile regression, or more generally nonparametric M-estimation, is proposed which is completely data-driven and adapts locally to the regularity of the regression function.
Yves Rozenholc +2 more
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
sparr: Analyzing Spatial Relative Risk Using Fixed and Adaptive Kernel Density Estimation in R
The estimation of kernel-smoothed relative risk functions is a useful approach to examining the spatial variation of disease risk. Though there exist several options for performing kernel density estimation in statistical software packages, there have ...
Tilman M. Davies +2 more
core
Adaptive nonlinear least bit error-rate detection for symmetrical RBF beamforming
, 2008 A powerful symmetrical radial basis function (RBF) aided detector is proposed for nonlinear detection in so-called rank-deficient multipleantenna assisted beamforming systems. By exploiting the inherent symmetry of the optimal Bayesian detection solution,
Chen, Sheng +3 more
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source