Results 111 to 120 of about 2,788,570 (251)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Adaptive Minimum-BER Linear Multiuser Detection for DS-CDMA Signals in Multipath Channels

, 2001
The problem of constructing adaptive minimum bit error rate (MBER) linear multiuser detectors is considered for direct-sequence code division multiple access (DS-CDMA) signals transmitted through multipath channels.
Mulgrew, B., Hanzo, L., Chen, S., Samingan, A.K.   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Distributed robust RLS estimation algorithm over sensor networks

Dianxin kexue, 2019
In the parameter estimation of the sensor network, there may be impact noise or pulse interference in the measurement environment, which leads to the outliers that greatly deviate from the actual range, so that the effective parameter estimation problem ...
Kaikai KANG, Zhaoting LIU, Yingbiao YAO
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Rotorcraft UAV actuator failure estimation with KF-based adaptive UKF algorithm

, 2008
A new adaptive Unscented Kalman Filter (UKF) algorithm for actuator failure estimation is proposed. The novel filter method with adaptability to statistical characteristic of noise is presented to improve the estimation accuracy of traditional UKE The ...
Qi JT(齐俊桐), Jianda Han, Wu ZW(吴镇炜), Zhenwei Wu, Juntong Qi, Han JD(韩建达)   +5 more
core   +1 more source

Unknown system dynamics estimator based control for sub‐synchronous oscillation of direct‐drive wind farms

IET Control Theory & Applications
Aiming at the problem of sub‐synchronous oscillations induced by direct‐drive wind farms with series‐compensated lines, this paper proposes an unknown system dynamics estimation‐based PI controller to achieve sub‐synchronous oscillation suppression ...
Xinze Xi, Min Wang, Chao Xing, Xincui Tian, Xian Wang   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Trajectory-Tracking Control for Quadrotors Using an Adaptive Integral Terminal Sliding Mode under External Disturbances

Drones
In the face of external disturbances affecting the trajectory tracking of quadrotors, a control scheme targeted at accurate position and attitude trajectory tracking was designed.
Shipeng Jiao, Jun Wang, Yuchen Hua, Ye Zhuang, Xuetian Yu   +4 more
doaj   +1 more source