Results 101 to 110 of about 2,788,570 (251)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Improving the adaptive moment estimation optimization methods for modern machine learning

open access: yes, 2020
Barner, Kenneth E.Optimization Algorithms for Neural Networks (NNs) have become a crucial and fundamental key in Artificial Intelligence. Inside Neural Networks architectures, adapting learning rates via an optimizer is a fundamental step in training ...
Alblwi, Abdalrahman
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Adaptive frequency-domain equalization for single-carrier MIMO systems [PDF]

open access: yes, 2004
Channel estimation and tracking pose real problems in wideband single-carrier wireless communication systems employing multiple transmit and receive antennas. An alternative to estimating the channel is to adaptively equalize the received symbols.
Coon, J   +7 more
core   +1 more source

Complexity L0-Penalized M-Estimation: Consistency in More Dimensions

open access: yesAxioms, 2013
We study the asymptotics in L2 for complexity penalized least squares regression for the discrete approximation of finite-dimensional signals on continuous domains—e.g., images—by piecewise smooth functions.
Gerhard Winkler   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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