Results 61 to 70 of about 148,393 (248)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Adaptive resilient control for a class of nonlinear distributed parameter systems with actuator faults

Systems Science & Control Engineering
This paper presents a new model-based fault resilient control scheme for a class of nonlinear distributed parameter systems (DPS) represented by parabolic partial differential equations (PDE) in the presence of actuator faults. A Luenberger-like observer
Hasan Ferdowsi, Jia Cai, Sarangapani Jagannathan   +2 more
doaj   +1 more source

Adaptive Black-Box Equivalent Modeling of Multiple Marine Micro-Grids Interconnected Through Subsea Cables

IEEE Access, 2018
The interconnection of different kinds of marine micro-grids (MMGs) with plug-and-play functionality is becoming popular, and a combined model is necessary to achieve the control functionalities and operation of the system constitute of several MMGs ...
Anan Zhang, Ming Cheng, Wei Yang, Qian Li, Janaka Ekanayake   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Predicting the Affordable Rate in Interference-Limited Cellular Systems Using Higher-Order Markov Models

IEEE Access, 2016
In cellular broadband access systems, such as 3GPP long-term evolution, the user equipment (UE) feeds back a quantized rate metric to the base station (eNodeB), in order to perform rate adaptation.
Saishankar Katri Pulliyakode, Sheetal Kalyani, Lajos Hanzo, K. Giridhar   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Adaptive Cardinality Estimation

, 2017
In this paper we address cardinality estimation problem which is an important subproblem in query optimization. Query optimization is a part of every relational DBMS responsible for finding the best way of the execution for the given query. These ways are called plans.
Ivanov, Oleg, Bartunov, Sergey
openaire   +2 more sources

Adaptive Estimation for Lévy Processes [PDF]

, 2014
This chapter is concerned with nonparametric estimation of the Lévy density of a Lévy process. The sample path is observed at $n$ equispaced instants with sampling interval $\Delta$. We develop several nonparametric adaptive methods of estimation based on deconvolution, projection and kernel. The asymptotic framework is: $n$ tends to infinity, $\Delta=\
Comte, Fabienne, Genon-Catalot, Valentine   +1 more
openaire   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source