Results 191 to 200 of about 1,014,656 (349)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations. [PDF]

Animals (Basel)
Zhang W, Yuan C, Guo T, Chen B, Wang F, Liu J, Lu Z.   +6 more
europepmc   +1 more source

Deep Reinforcement Learning for Adaptive Parameter Control in Differential Evolution for Multi-Objective Optimization

, 2022
Robbert Reijnen, Yingqian Zhang, Zaharah Bukhsh, Mateusz Guzek   +3 more
openalex   +2 more sources

MORGAN ON EVOLUTION AND ADAPTATION [PDF]

Science, 1904
openaire   +2 more sources

The Evolution of Kleptoparasitism under Adaptive Dynamics Without Restriction [PDF]

, 2008
Broom, M., Rychtar, J., Sykes, C.
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Space-time adaptive wavelet methods for parabolic evolution problems [PDF]

, 2009
Christoph Schwab, Rob Stevenson
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparative chloroplast genomics of Cypripedioideae: structural divergence, adaptive evolution, and phylogenomic insights. [PDF]

Front Plant Sci
Zhao X, Lan X, Wang Z, Li D, Sun W, Gai Y, Liu B.   +6 more
europepmc   +1 more source

An Adaptive Lagrangian B-Spline Framework for Point Cloud Manifold Evolution

Muhammad Ammad, Leevan Ling
openalex   +1 more source