Results 21 to 30 of about 109,797 (269)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Adaptive Quotient Filters [PDF]
Proceedings of the ACM on Management of DataFilters trade off accuracy for space and occasionally return false positive matches with a bounded error. Numerous systems use filters in fast memory to avoid performing expensive I/Os to slow storage. A fundamental limitation in traditional filters is that they do not change their representation upon seeing a false positive match.
Richard Wen +8 more
openaire +2 more sources
Adaptive acoustooptic filter [PDF]
Applied Optics, 1984 A new adaptive filter utilizing acoustooptic devices in a space integrating architecture is described. Two configurations are presented; one of them, suitable for signal estimation, is shown to approximate the Wiener filter, while the other, suitable for detection, is shown to approximate the matched filter.
D, Psaltis, J, Hong
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
An Efficient Scheme for Broadband Adaptive Beamforming
, 1999 This paper introduces an oversampled subband approach to linearly constrained minimum variance adaptive broadband beamforming. This method is motivated by the considerable reduction in computation over fullband implementation and resulting large ...
S. Weiss +18 more
core +1 more source
An oversampled subband adaptive filter without cross adaptive filters [PDF]
Signal Processing, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Moritz Harteneck +2 more
openaire +2 more sources