Results 141 to 150 of about 5,026,401 (367)

149 Differences in Gene Expression Following Natural Exposure to Gastrointestinal Parasites between Sheep Selected for High Innate Responses and High Antibody-Mediated Adaptive Immune Responses [PDF]

, 2022
Olivia Willoughby, Emma Borkowski, S. E. Dixon, Samla M F Cunha, Victoria Asselstine, Andrew S Perergrine, Paula Menzies, Niel A. Karrow, Ángela Cánovas   +8 more
openalex   +1 more source

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Nature Genetics, 2015
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens.
J. Bentham, D. Morris, D. C. Cunninghame Graham, C. Pinder, Philip Tombleson, T. Behrens, Javier Martín, B. Fairfax, J. Knight, Lingyan Chen, J. Replogle, A. Syvänen, L. Rönnblom, R. Graham, J. Wither, J. Rioux, M. Alarcón-Riquelme, T. Vyse   +17 more
semanticscholar   +1 more source

Adaptive Immunity [PDF]

Stroke, 2007
The 3 talks in this session all deal with aspects of immune response regulation and dysregulation that can be either protective or harmful in brain ischemia. As an introduction to this session, I will review several models of immune response regulation and relate these models to the upcoming talks.1 Under normal circumstances, antigen presenting cells (
openaire   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

, 2016
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the ...
Ada W.C. Yan, Antia, Badovinac, Barber, Beauchemin, Blattman, Bocharov, Bodewes, Boianelli, Boon, Bortnick, Braciale, Brown, Brown, Bui, Cao, Carolan, Carpenter, Chao, Christensen, Crowe, Davenport, De Boer, Dobrovolny, Epstein, Faroudi, Grayson, Grebe, Greenbaum, Hancioglu, Handel, Hou, Iwasaki, James M. McCaw, Jameson, Jane M. Heffernan, Jodie McVernon, Kaech, Kaech, Karen L. Laurie, Kees, Komadina, Kreijtz, Kris, Kylie M. Quinn, Laurie, Laurie, Lee, Lehmann-Grube, Luciani, Luckheeram, Marchuk, Martin, McElhaney, McMichael, Mehlhop-Williams, Miao, Miao, Murali-Krishna, Nicole L. La Gruta, Nowak, Pawelek, Pengxing Cao, Petrie, Quinn, Rammensee, Selin, Shin, Smith, Smith, Smith, Sridhar, Steel, Sze, Tanchot, Terajima, Tscharke, van Stipdonk, Veiga-Fernandes, Veiga-Fernandes, Wells, Wherry, Wirth, Wodarz, Wodarz, Yan, Yap, Yewdell, Yewdell, Zarnitsyna, Zehn   +90 more
core   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

Frontiers in Immunology
BackgroundT cells play a crucial role in the adaptive immune response against acute virus infections. The extensive diversity of T cell receptors (TCRs) presents a complex challenge for understanding its implications in immune responses.
Maria A. Salnikova, Maria A. Salnikova, Maria A. Salnikova, Ksenia K. Tuchynskaya, Anastasia A. Minervina, Mikhail V. Pogorelyy, Egor V. Okhezin, Galina G. Karganova, Galina G. Karganova, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev   +11 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

, 2013
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C, Martins, Marcelo L, Paiva, Leticia R, Silva, Hallan S   +3 more
core   +2 more sources

Rotavirus A Inoculation and Oral Vitamin A Supplementation of Vitamin A Deficient Pregnant Sows Enhances Maternal Adaptive Immunity and Passive Protection of Piglets against Virulent Rotavirus A [PDF]

, 2022
Juliet Chepngeno, Joshua O. Amimo, Husheem Michael, Kwonil Jung, Sergei A. Raev, Marcia V. Lee, Debasu Damtie, Alfred O. Mainga, Anastasia N. Vlasova, Linda J. Saif   +9 more
openalex   +1 more source