Results 221 to 230 of about 5,026,401 (367)

Identification of preexisting adaptive immunity to Cas9 proteins in humans

Nature Medicine, 2018
Carsten T. Charlesworth, Priyanka S. Deshpande, D. Dever, J. Camarena, Viktor T. Lemgart, M. Cromer, Christopher A. Vakulskas, Michael A. Collingwood, Liyang Zhang, Nicole M. Bode, M. Behlke, Beruh T. Dejene, Brandon Cieniewicz, R. Romano, Benjamin J. Lesch, N. Gomez-Ospina, Sruthi Mantri, Mara Pavel-Dinu, Kenneth I. Weinberg, M. Porteus   +19 more
semanticscholar   +1 more source

Highly Sensitive Electrochemical Biosensor Based on Hairy Particles with Controllable High Enzyme Loading and Activity

Advanced Functional Materials, EarlyView.
For the first time, a highly sensitive electrochemical biosensor based on SiO2‐based hairy particles with a grafted PDMAEMA polymer brush containing a quantifiable and large amount of immobilized Laccase is reported. The fabricated biosensor exhibits a sensitivity of 0.14 A·m⁻¹, a limit of detection (LOD) of 0.1 µm, and a detection range of 0.3–750 µm,
Pavel Milkin, Anila Antony, Hongtao Cai, Antonia Debevc, Ceyda Topal, Anne Linhardt, Alla Synytska, Leonid Ionov   +7 more
wiley   +1 more source

Activation and Long-Term Maintenance of Adaptive Immunity in the Central Nervous System: A Double-Edged Sword? [PDF]

CNS Neurosci Ther
Wang L, Zhang F, Wu J, Yang S, Zhou D, Sun X, Chang B, Hu B, Zhou Y.   +8 more
europepmc   +1 more source

Hypoxia stimulus: An adaptive immune response during dendritic cell maturation [PDF]

, 2008
Inés Rama, Bernhard Bruene, Joan Torrás, Robert H. Koehl, Josep M. Cruzado, Oriol Bestard, Marcella Franquesa, Núria Lloberas, Andreas Weigert, I. Herrero, Òscar Gulías, Josep M. Grinyó   +11 more
openalex   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Modulating antigen processing through metal-organic frameworks to bias adaptive immunity. [PDF]

Proc Natl Acad Sci U S A
Cho E, Davis MA, Nowak JA, Izzo M, Ferrante AM, Sha F, Magdalenski JS, Farha OK, Teplensky MH.   +8 more
europepmc   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues. [PDF]

Immunol Rev
Olson EC, Williams A, Eisenbarth SC.
europepmc   +1 more source

Faculty Opinions recommendation of Compartmentalized gut lymph node drainage dictates adaptive immune responses.

, 2019
Philippe Saas, Sylvain Perruche
openalex   +2 more sources

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source