Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
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Effect of adaptive laboratory evolution of engineered Escherichia coli in acetate on the biosynthesis of succinic acid from glucose in two-stage cultivation. [PDF]
Bioresour BioprocessJiang J +7 more
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Adaptive laboratory evolution reveals regulators involved in repressing biofilm development as key players in Bacillus subtilis root colonization. [PDF]
mSystemsPomerleau M +5 more
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Adaptive laboratory evolution principles and applications in industrial biotechnology
Biotechnology Advances, 2022Adaptive laboratory evolution (ALE) is an innovative approach for the generation of evolved microbial strains with desired characteristics, by implementing the rules of natural selection as presented in the Darwinian Theory, on the laboratory bench. New as it might be, it has already been used by several researchers for the amelioration of a variety of
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Improving carotenoids production in yeast via adaptive laboratory evolution
Metabolic Engineering, 2014Adaptive laboratory evolution is an important tool for the engineering of strains for industrially relevant phenotypes. Traditionally, adaptive laboratory evolution has been implemented to improve robustness of industrial strains under diverse operational conditions; however due to the required coupling between growth and survival, its application for ...
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Application of adaptive laboratory evolution for Yarrowia lipolytica: A comprehensive review
Bioresource TechnologyAdaptive laboratory evolution is an innovative approach utilized by researchers to enhance the characteristics of microorganisms in the field of biology. With the advancement of this technology, it is now being extended to non-model strains. Yarrowia lipolytica, an oleaginous yeast with significant industrial potential, stands out among the non ...
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Genetic Diversity for Accelerating Microbial Adaptive Laboratory Evolution
ACS Synthetic Biology, 2021Adaptive laboratory evolution (ALE) is a widely used and highly effective tool for improving microbial phenotypes and investigating the evolutionary roots of biological phenomena. Serving as the raw materials of evolution, mutations have been extensively utilized to increase the chances of engineering molecules or microbes with tailor-made functions ...
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Adaptive laboratory evolution for growth coupled microbial production
World Journal of Microbiology and Biotechnology, 2020Adaptive laboratory evolution (ALE) is a powerful tool to select for strains with growth-coupled phenotypes. When coupled with next-generation sequencing and omic technologies, genotype-to-phenotype relationships and the molecular mechanisms underlying desired complex phenotypes can now be uncovered using ALE.
Avinash Godara, Katy C. Kao
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Nutrient acclimation in benthic diatoms with adaptive laboratory evolution
Bioresource Technology, 2022The growth of marine diatom algaeChaetoceros gracilisandThalassiosira weissflogiiin agricultural fertilizers and additional carbon sources were evaluated. The main objective behind the study was to increase the growth and productivity of the diatom acclimatized under adaptive laboratory culture conditions.
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