Results 51 to 60 of about 1,291,053 (287)
Фізико-математична освіта, 2022 Formulation of the problem. In the context of online / blended learning, the relevance of research on the use of digital technologies as a means of adaptive learning for higher education in computer science and mathematics is undeniable.
Олена Косовець +3 more
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The design and implementation of an adaptive e-learning system [PDF]
, 2007 This paper describes the design and implementation of an adaptive e-learning system that provides a template for different learning materials as well as a student model that incorporates five distinct student characteristics as an aid to learning ...
Surjono, Herman Dwi
core
Coherent control using adaptive learning algorithms
, 2001 We have constructed an automated learning apparatus to control quantum systems. By directing intense shaped ultrafast laser pulses into a variety of samples and using a measurement of the system as a feedback signal, we are able to reshape the laser ...
A. Assion +32 more
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Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Development of visual-stimulus reversal learning-memory in mice is dependent on social interaction
iScienceSummary: Flexible learning about visual stimuli and reward was investigated in male mice in terms of development, social stimulation, and memory. In a sucrose foraging task, mice learned that one of the two complex visual stimuli was correct (compound ...
Sarah Wicki +5 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Examining Adaptive E-Learning Approaches to Enhance Learning and Individual Experiences
Acta Informatica PragensiaThe concept of individualization has emerged as an essential advance in education, representing a paradigm shift adopted by educational systems worldwide. This paradigm evolution aims to optimize student performance by harnessing the potential of diverse
Fateh Benkhalfallah +2 more
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