Results 61 to 70 of about 1,291,053 (287)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Problems and Prospects for the Application of Neural Networks for the Sphere of Education

open access: yesОткрытое образование (Москва), 2022
The purpose of the study is to examine the theory and practice of using neural networks in education, to develop the concept of a neural network adaptive learning environment, and to implement a neural network model of one of the subsystems of this ...
T. M. Shamsutdinova
doaj   +1 more source

Adaptive learning program for developing employability skills [PDF]

open access: yes, 2018
The paper aims to demonstrate the benefits of adaptive learning technologies as a viable alternative to time consuming tutor led individual support. It proposes to reveal how adaptive learning interventions can be effective in enriching student learning ...
Jackson, Timothy P., Oliver, Stanley
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

A new method to detect attacks on the Internet of Things (IoT) using adaptive learning based on cellular learning automata

open access: yesETRI Journal, 2021
The Internet of Things (IoT) is a new paradigm that connects physical and virtual objects from various domains such as home automation, industrial processes, human health, and monitoring. IoT sensors receive information from their environment and forward
Javad Dogani   +2 more
doaj   +1 more source

Defining Adaptive Learning Paths For Competence-Oriented Learning [PDF]

open access: yes, 2008
This paper presents a way to describe educational itineraries in a competence-oriented learning system in order to solve the problem of sequencing several independent courses.
González Abril, Luis   +5 more
core  

Adaptivity and ‘Per learning’ [PDF]

open access: yesPhysica A: Statistical Mechanics and its Applications, 2004
8 pages, 4 figures.
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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