Results 71 to 80 of about 9,004,624 (359)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Adaptive Learning-Based Task Offloading for Vehicular Edge Computing Systems [PDF]

IEEE Transactions on Vehicular Technology, 2019
The vehicular edge computing system integrates the computing resources of vehicles, and provides computing services for other vehicles and pedestrians with task offloading. However, the vehicular task offloading environment is dynamic and uncertain, with
Yuxuan Sun, Xueying Guo, Jinhui Song, Sheng Zhou, Zhiyuan Jiang, Xin Liu, Z. Niu   +6 more
semanticscholar   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Development of visual-stimulus reversal learning-memory in mice is dependent on social interaction

iScience
Summary: Flexible learning about visual stimuli and reward was investigated in male mice in terms of development, social stimulation, and memory. In a sucrose foraging task, mice learned that one of the two complex visual stimuli was correct (compound ...
Sarah Wicki, Annika Canziani, Giulia Poggi, Ali Özgür Argunşah, Theofanis Karayannis, Christopher R. Pryce   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Implementing the Adaptive Learning Techniques

Вопросы образования, 2020
The concept of adaptive learning emerged a few decades ago, but most theoretical findings have never been put into practice, and software solutions had no significant reach for a long time due to insufficient e-learning technology development and ...
Ivan Krechetov, Vladimir Romanenko
doaj   +1 more source

On Distributed Cognition While Designing an AI System for Adapted Learning

Frontiers in Artificial Intelligence, 2022
When analyzing learning, focus has traditionally been on the teacher, but has in the recent decades slightly moved toward the learner. This is also reflected when supporting systems, both computer-based and more practical equipment, has been introduced ...
Magne V. Aarset, Magne V. Aarset, Leiv Kåre Johannessen   +2 more
doaj   +1 more source

Adaptive Online Learning

CoRR, 2015
We propose a general framework for studying adaptive regret bounds in the online learning framework, including model selection bounds and data-dependent bounds. Given a data- or model-dependent bound we ask, "Does there exist some algorithm achieving this bound?" We show that modifications to recently introduced sequential complexity measures can be ...
Dylan J. Foster, Alexander Rakhlin, Karthik Sridharan   +2 more
openaire   +3 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

An agent-based approach to dynamic adaptive learning [PDF]

, 2005
Dynamic adaptive learning and teaching strategies are increasingly demanded in order to improve the efficiency and effectiveness of the education process, but few learning systems exist which are dynamic and able to satisfy individual students.
Sun, Shanghua, Joy, Mike, Griffiths, Nathan   +2 more
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