Results 61 to 70 of about 251,924 (243)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing

open access: yesNature Communications
The role of developmental cell death in the formation of brain circuits is not well understood. Cajal-Retzius cells constitute a major transient neuronal population in the mammalian neocortex, which largely disappears at the time of postnatal ...
Angeliki Damilou   +10 more
doaj   +1 more source

Adaptive Intelligent Learning Environments [PDF]

open access: yes, 2017
Adaptive intelligent learning environments (AILE) seek to optimize the learning process for every individual learner. To this end, they create and maintain models of domain knowledge, instructional activities and the learners themselves. AILE is an active area of research that can be traced back to the 1970s.
Herder, Eelco   +2 more
openaire   +3 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Implementasi Pembelajaran Cake Decoration pada Siswa Berkebutuhan Khusus (Tunarungu) oleh Politeknik Pariwisata Makassar

open access: yesBhakti Persada: Jurnal Aplikasi Ipteks
This community service project aims to implement cake decoration learning for deaf students at SLB.C YPPLB 2 Makassar. This program is a collaboration between the Makassar Tourism Polytechnic and SLB.C YPPLB 2 Makassar, aiming to provide vocational ...
Faisal Akbar Zaenal   +4 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Toward an adaptive learning assessment pathway

open access: yesFrontiers in Education
The purpose of this study is to investigate how an adaptive assessment pathway can contribute to promoting personalized learning and improving access to education for all learners, regardless of their individual learning styles, paces, or needs.
Mounia Machkour   +4 more
doaj   +1 more source

Research on AIGC-Driven Personalized Mathematics Learning System [PDF]

open access: yesSHS Web of Conferences
This paper comprehensively explores the development, implementation, and impact of an AIGC (Artificial Intelligence-Generated Content)-driven personalized mathematics learning system.
Wang Chenggang
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Intelligent Learning Support System

open access: yesProceedings of the International Conference on Applied Innovations in IT
Modern educational processes require automation to improve learning efficiency. The use of artificial intelligence (AI) allows to optimize the management of the learning process, increase the personalization of learning, and automate assessment.
Eugene Karashevych   +2 more
doaj   +1 more source

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