Results 61 to 70 of about 43,903 (287)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Adaptive Under Frequency Load Shedding Scheme Using Genetic Algorithm Based Artificial Neural Network [PDF]
Journal of Electrical and Electronics Engineering, 2019 This paper presents two schemes of UFLS to keep the system frequency within safe limits. GA-based scheme is introduced as an offline method to get the proper amount of shed load achieving the minimum and steady state frequency within permissible limits ...
ELZAWAWY Ahmed +3 more
doaj
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Applied SciencesBidirectional Interleaved Converters (BICs) are widely used in Battery Energy Storage Systems (BESSs) due to their modular structure, high efficiency, and reduced current ripple. However, under partial-load operation, conventional control strategies with
Andrej Brandis +3 more
doaj +1 more source
High Specification Offshore Blades. Work Package: 1C – Blade Materials. [PDF]
, 2008 Blades are regarded as the only component unique to wind turbine blades. They represent only 10 – 15% of the total system cost so the perception is that a reduction in the cost of energy through blade cost improvements is constrained.
York, Christopher
core
Oxide‐Free Titanium Coatings by Wire Arc Spraying in a Silane‐Doped Inert Atmosphere
Advanced Engineering Materials, EarlyView.A silane‐doped argon atmosphere enables the production of oxide‐free titanium coatings via twin‐wire arc spraying at ambient pressure. This innovative approach eliminates residual oxygen, creating process conditions that prevent oxidation and nitride formation.
Manuel Rodriguez Diaz +4 more
wiley +1 more source
Energies, 2017 As the requirements of economical operation and reliability on power grid are enhanced gradually nowadays, the existing under frequency load shedding (UFLS) scheme is not quite fit for the modern power system that integrates high wind power.
Shun Li +3 more
doaj +1 more source
Energies, 2020 The lack of synchronous inertia, associated with the relevant penetration of variable speed wind turbines (VSWTs) into isolated power systems, has increased their vulnerability to strong frequency deviations.
Ana Fernández-Guillamón +3 more
doaj +1 more source