Results 41 to 50 of about 342,937 (270)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Generation of the therapeutic monoclonal antibody NEO-201, derived from a cancer vaccine, which targets human malignancies and immune suppressor cells

Expert Review of Vaccines
Introduction Cancer vaccines stimulate the activation of specific humoral and cellular adaptive responses against cancer cells.Antibodies generated post vaccination can be isolated and further selected to develop highly specific and potent monoclonal ...
Massimo Fantini, Kwong Y. Tsang, Philip M. Arlen   +2 more
doaj   +1 more source

Adaptive Output Feedback MPC With Guaranteed Stability and Robustness

IEEE Transactions on Automatic Control
This work proposes an adaptive output feedback model predictive control (MPC) framework for uncertain systems subject to external disturbances. In the absence of exact knowledge about the plant parameters and complete state measurements, the MPC optimization problem is reformulated in terms of their estimates derived from a suitably designed robust ...
Anchita Dey, Shubhendu Bhasin
openaire   +2 more sources

Robust Global Adaptive Exponential Stabilization of Discrete-Time Systems With Application to Freeway Traffic Control [PDF]

IEEE Transactions on Automatic Control, 2015
This paper is devoted to the development of adaptive control schemes for uncertain discrete-time systems, which guarantee robust global exponential convergence to the desired equilibrium point of the system.
I. Karafyllis, Maria Kontorinaki, M. Papageorgiou   +2 more
semanticscholar   +1 more source

Static output-feedback stabilization of discrete-time Markovian jump linear systems: a system augmentation approach [PDF]

, 2010
This paper studies the static output-feedback (SOF) stabilization problem for discrete-time Markovian jump systems from a novel perspective. The closed-loop system is represented in a system augmentation form, in which input and gain-output matrices are ...
Lam, James, Xiong, J, Xiong, Junlin, Shu, Z, Lam, J, Shu, Zhan   +5 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An Analytical Comparison between the weighted LQ performance of a robust and an Adaptive Backstepping Design

, 2002
A robust and an adaptive backstepping design for an uncertain strict feedback system are compared with respect to a cost functional which is based on an instantaneous quadratic penalty measuring both the output transient and the control effort.
French, MC
core   +1 more source

Analysis of Stability and Adaptive Control of Brusselator System in Maintained Chemical Reaction

Journal of Applied Mathematics
This paper investigates the stability and adaptive control of a three-dimensional maintained Brusselator system modeling autocatalytic chemical reactions with continuous inflow.
Kumera Takele Yadeta, Mitiku Daba Firdi, Tamirat Temesgen Dufera   +2 more
doaj   +1 more source

Conformational alterations in the protein-DNA complex facilitates efficient integration of diverse DNA substrates by the CRISPR Cas1-Cas2 proteins [PDF]

Structural Dynamics
CRISPR-Cas [clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated] systems are adaptive immune systems present in bacteria and archaea to fight invading genetic elements.
Alberto Monteiro Dos Santos, Saadi Rostami, Richard Van, Kole Long, Swarmistha Devi Aribam, Yihan Shao, Rakhi Rajan   +6 more
doaj   +1 more source