Results 161 to 170 of about 3,973,865 (282)

Influence of incident particle energy on DNA damage formation in a pUC19 plasmid: A Geant4-DNA study

Journal of Radiation Research and Applied Sciences
Understanding how radiation quality and particle energy influence DNA damage formation is essential for radiation biology, radiation protection, and particle therapy applications. In this study, the Geant4-DNA track-structure Monte Carlo toolkit (version
Samar A. Alghamdi, Naseeba N. Alotaiq, Nusaiba S. Satti, Wasmia M. Dahan, Tarig G. Ibrahim, Omamah H. Alnaseef, Hanan F. Akhdar   +6 more
doaj   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Strategy to select nasopharyngeal cancer patients for adaptive radiotherapy

Frontiers in Oncology
BackgroundNasopharyngeal cancer (NPC) patients experience significant anatomical changes during radiation treatment (RT). Adaptive radiotherapy (ART) can be initiated in response to specific events or at scheduled intervals during treatment, prompting ...
Heleen Bollen, Heleen Bollen, Elena Onorati, Annouschka Laenen, Anneleen Goedgebeur, Sandra Nuyts, Sandra Nuyts   +6 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

A versatile phantom-based framework for end-to-end testing of (online) adaptive proton therapy in the head-and-neck region.

Radiotherapy and Oncology
BACKGROUND AND PURPOSE Clinical implementation of online adaptive proton therapy requires rigorous testing of all facility-specific components. This work aimed to develop a multi-purpose phantom-based framework capable of testing the efficacy of diverse ...
Jacob Brunner, F. Albertini, G. P. Bernardini, S. Bertschi, S. Both, E. Choulilitsa, Dietmar Georg, S. Korreman, G. Marmitt, K. Poels, C. Richter, E. Sterpin, M. Stock, K. Stützer, N. Vatterodt, B. Knäusl   +15 more
semanticscholar   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

A global bibliometric and visualization study of the adaptive radiotherapy research landscape

Discover Oncology
The clinical application of adaptive radiotherapy (ART) remains limited in practice, mainly due to equipment limitations and time constraints. This analysis aims to uncover prevalent research patterns, emerging trends, and collaborative networks to guide
Zhengyu Zhou, Chuan Huang, Xiaoying Li, Yihan Ye, Man Wang, Qiongyu Lan, Qing Li   +6 more
doaj   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source

Integrating Structure Propagation Uncertainties in the Optimization of Online Adaptive Proton Therapy Plans. [PDF]

Cancers (Basel), 2022
Nenoff L, Buti G, Bobić M, Lalonde A, Nesteruk KP, Winey B, Sharp GC, Sudhyadhom A, Paganetti H.   +8 more
europepmc   +1 more source