Results 141 to 150 of about 3,973,865 (282)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

PAMELA : overview and status [PDF]

, 2010
The status of the PAMELA (Particle Accelerator for MEdical Applications) project to design an accelerator for proton and light ion therapy using non-scaling Fixed Field Alternating Gradient (ns-FFAG) accelerators is reviewed and ...
Easton, M.J., Tzenov, S.I., Pasternak, J., Witte, H., Johnstone, C., Edgecock, T. R., Machida, S., Cobb, J., Barlow, R. J., Fenning, R.J.L., Vojnovic, B., Owen, H. L., Pattalwar, S., Jones, B., Yokoi, T., Tygier, S.C., Gardner, I.S.K., Witte, H, Hill, M.A., Beard, Carl, Peach, K., Fenning, R., Hill, M., Khan, A., McIntosh, P.A., Bliss, N., Seviour, R., Tygier, S., Edgecock, R., Kelliher, D.J., Tzenov, S., Jones, T.J., Cobb, J H, Smith, S. L., Peach, K. J., Kelliher, D., Pattalwar, S.M., Barlow, Roger, Sheehy, S. L., Aslaninejad, M., Easton, M., Beard, C.D., Pozimski, J.K., Owen, H., Gardner, I. S K, Seviour, Rebecca, Strachan, J., McIntosh, P., Pozimski, Jürgen Klaus, Smith, S.L., Jones, T.   +50 more
core   +2 more sources

Proton dose calculation on cone-beam computed tomography using unsupervised 3D deep learning networks

Physics and Imaging in Radiation Oncology
Background and Purpose: Poor image quality of cone-beam computed tomography (CBCT) images can hinder proton dose calculation to assess the influence of anatomy changes.
Casper Dueholm Vestergaard, Ulrik Vindelev Elstrøm, Ludvig Paul Muren, Jintao Ren, Ole Nørrevang, Kenneth Jensen, Vicki Trier Taasti   +6 more
doaj   +1 more source

A Novel Imaging System for Adaptive Proton Therapy [PDF]

International Journal of Radiation Oncology*Biology*Physics, 2017
J.A. Oliver, O.A. Zeidan, S. Meeks, A.P. Shah, J. Pukala, P. Kelly, N.R. Ramakrishna, T. Willoughby   +7 more
openaire   +1 more source

Dosimetric Comparison and Selection Criteria of Intensity-Modulated Proton Therapy and Intensity-Modulated Radiation Therapy for Adaptive Re-Plan in T3-4 Nasopharynx Cancer Patients

Background: Proton therapy requires caution when treating patients with targets near neural structures. Intuitive and quantitative guidelines are needed to support decision-making concerning the treatment modality. This study compared dosimetric profiles
Dong Yeol Kwon, Kyungmi Yang, Kisung Lee, Yong Chan Ahn, Yeong-bi Kim, Sang Gyu Ju, Dongryul Oh, Seyjoon Park, Mincheol Ko   +8 more
core   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Balancing robustness and adaptation rate for proton therapy of lung cancer patients

Radiotherapy and Oncology
An increase in plan robustness leads to a higher dose to organs-at-risk (OARs), and an increased chance of post-treatment toxicities. In contrast, more conformal plans lead to sparing of healthy surrounding tissue at the expense of a higher sensitivity to anatomical changes, requiring costly adaptations.
Badiu, Vlad, Taasti, Vicki Trier, Defraene, Gilles, van Elmpt, Wouter, Sterpin, Edmond   +4 more
openaire   +3 more sources

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

A decade of radiotherapy: Clinical evolution, technological innovation, and the challenge of cardiotoxicity

Nuclear Engineering and Technology
Radiotherapy transformed in 2015–2025, moving from incremental change to biologically informed, image-guided and increasingly automated care. This narrative review, informed by a comprehensive literature search of major databases (2015–2025), synthesises
Emmanuel O. Oisakede, Babajide F. Ajeyomi, Olawunmi O. Oyedeji, Oluwakemi Jumoke Bello, Claret Chinenyenwa Analikwu, David B. Olawade   +5 more
doaj   +1 more source