Results 151 to 160 of about 3,973,865 (282)

Predicting dose accumulation reliability at the planning stage, with an application to adaptive proton therapy

Physics in Medicine and Biology
Objective. Online adaptive proton therapy could benefit from reoptimization that considers the total dose delivered in previous fractions. However, the accumulated dose is uncertain because of deformable image registration (DIR) uncertainties.
A. Smolders, A. J. Lomax, F. Albertini
semanticscholar   +1 more source

Fast Monte Carlo dose calculation in proton therapy. [PDF]

This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customization and precision.
Zhang, Lian, Holmes, Jason, Fix, Michael K, Liu, Wei, Jiang, Steve B, Feng, Hongying   +5 more
core   +2 more sources

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Cone beam CT-based adaptive intensity modulated proton therapy assessment using automated planning for head-and-neck cancer

Radiation Oncology
Background To assess the feasibility of CBCT-based adaptive intensity modulated proton therapy (IMPT) using automated planning for treatment of head and neck (HN) cancers.
Yihang Xu, William Jin, Michael Butkus, Mariluz De Ornelas, Jonathan Cyriac, Matthew T. Studenski, Kyle Padgett, Garrett Simpson, Stuart Samuels, Michael Samuels, Nesrin Dogan   +10 more
doaj   +1 more source

Clinical implementation of intensity modulated proton therapy for testicular seminoma

Acta Oncologica
Background and purpose: We have previously shown that proton therapy results in considerable reduced doses to abdominal organs at risk (OAR) which likely reduces the patient’s risk of a second malignant tumor, which is vital for this young population ...
Heidi S. Rønde, Jesper F. Kallehauge, Morten Høyer, Anne Birgitte Als, Mads Agerbæk, Jakob Lauritsen, Peter M. Petersen, Lars Dysager, Camilla J.S. Kronborg   +8 more
doaj   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Risk-adapted Optimization in Intensity Modulated Proton Therapy (IMPT) [PDF]

, 2008
Due to the pronounced dose gradients generated by proton beams, proton treatment plans can be very sensitive to treatment uncertainties. However in IMPT many different solutions of the inverse problem exist which result in dose distributions of comparable quality.
openaire   +1 more source

A critical appraisal of the clinical utility of proton therapy in oncology

, 2015
Dongxu WangDepartment of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAAbstract: Proton therapy is an emerging technology for providing radiation therapy to cancer patients.
Wang D
core  

Multimodal Bioinspired Self‐Healing Composites Enabling Durable and High‐Efficiency Wearable Perovskite Light‐Emitting Diodes

Advanced Science, EarlyView.
Butterfly wing–inspired intrinsically self‐healing polymer interlayers enable flexible perovskite optoelectronics with high luminance, strain‐insensitive stability, and environmental resilience. These hierarchically structured films redistribute mechanical stress, suppress defect formation, and maintain performance under repeated bending, paving the ...
Loganathan Veeramuthu, Yu‐Chen Wang, Chun‐Tse Tsai, Yen‐Lin Tseng, Xuan Ting King, Tzu‐Ming Hsu, Zhen‐Li Yan, Fang‐Cheng Liang, Pei‐Yin Chen, Georgy Dosovitskiy, Yehonadav Bekenstein, Hyunjin Lee, Tao Zhou, Chi‐Ching Kuo   +13 more
wiley   +1 more source