Results 51 to 60 of about 366,081 (322)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The contribution of evolvability to the eco‐evolutionary dynamics of competing species
Ecology and Evolution, 2023 Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms.
Anuraag Bukkuri +5 more
doaj +1 more source
Finite Element simulation of radiation losses in photonic crystal fibers
, 2007 In our work we focus on the accurate computation of light propagation in finite size photonic crystal structures with the finite element method (FEM).
Burger, Sven +4 more
core +1 more source
Dynamic patterns of adaptive radiation [PDF]
Proceedings of the National Academy of Sciences, 2005 Adaptive radiation is defined as the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. When it occurs, adaptive radiation typically follows the colonization of a new environment or the establishment of a “key innovation,” which opens new ecological niches and/or new paths for evolution.
Sergey, Gavrilets, Aaron, Vose
openaire +2 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Journal of Ecology and EnvironmentBackground: Hypersaline environments (> 40 practical salinity units [PSU]) represent some of the most extreme conditions on Earth, supporting a variety of halophilic and halotolerant bacteria, archaea, and protists.
Hyeon Been Lee, Jong Soo Park
doaj +1 more source
Adaptive Radiation for Lung Cancer [PDF]
Journal of Oncology, 2011 The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such as four-dimensional (4D) image-based motion management, daily on-board imaging and adaptive radiotherapy based on volumetric images over the course of ...
Gomez, Daniel R., Chang, Joe Y.
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Real‐time motion monitoring using orthogonal cine MRI during MR‐guided adaptive radiation therapy for abdominal tumors on 1.5T MR‐Linac [PDF]
, 2023 Hassan Jassar +11 more
openalex +1 more source