Results 71 to 80 of about 83,753 (298)

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol

BMC Cancer
Background Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue.
Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson, Eva Serup-Hansen   +5 more
doaj   +1 more source

Advances on Clinical Application of Adaptive Radiotherapy in Treatment of Nasopharyngeal Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Radiotherapy is the first treatment choice for nasopharyngeal carcinoma. With the rapid development of image-guided radiotherapy, adaptive radiotherapy (ART) has become widely available in clinical practice.
ZHANG Yucong, XU Gang
doaj   +1 more source

IMRT QA using machine learning: A multi-institutional validation. [PDF]

, 2017
PurposeTo validate a machine learning approach to Virtual intensity-modulated radiation therapy (IMRT) quality assurance (QA) for accurately predicting gamma passing rates using different measurement approaches at different institutions.MethodsA Virtual ...
Chan, Maria F, Deasy, Joseph O, Lim, Seng Boh, Scheuermann, Ryan, Solberg, Timothy D, Valdes, Gilmer   +5 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The grid-dose-spreading algorithm for dose distribution calculation in heavy charged particle radiotherapy [PDF]

, 2007
A new variant of the pencil-beam (PB) algorithm for dose distribution calculation for radiotherapy with protons and heavier ions, the grid-dose spreading (GDS) algorithm, is proposed.
Ahnesjö, Azusa Ishizaki, Bortfeld, Deasy, Endo, Hollmark, Hong, Kanai, Kanematsu, Kanematsu, Kanematsu, Kanematsu, Kanematsu, Kohno, Krämer, Langen, Lomax, Mackie, Mackie, Nobuyuki Kanematsu, Noda, Petti, Russell, Schaffner, Sharpe, Shunsuke Yonai, Soukup, Szymanowski, Tsuji, Yan   +29 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A GPU-based finite-size pencil beam algorithm with 3D-density correction for radiotherapy dose calculation

, 2011
Targeting at the development of an accurate and efficient dose calculation engine for online adaptive radiotherapy, we have implemented a finite size pencil beam (FSPB) algorithm with a 3D-density correction method on GPU.
Court L E, Fippel M, Fu W H, Gu X J, Gu X J, Gu X J, Jelen U, Jelen U, Jia X, Jiang S B, Jinsheng Li, Lu W G, Lu W G, Lu W G, Ma C-M, Men C H, Men C H, NVIDIA, Sharp G C, Steve B Jiang, Urszula Jelen, Wu C, Wu Q J, Xuejun Gu, Xun Jia   +24 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Expanding the use of real-time electromagnetic tracking in radiation oncology. [PDF]

, 2011
In the past 10 years, techniques to improve radiotherapy delivery, such as intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT) for both inter- and intrafraction tumor localization, and hypofractionated delivery techniques ...
Kupelian, Patrick A, Meeks, Sanford L, Shah, Amish P, Willoughby, Twyla R   +3 more
core   +1 more source