Results 71 to 80 of about 1,387,215 (249)

The Role of Machine Learning in Knowledge-Based Response-Adapted Radiotherapy

Frontiers in Oncology, 2018
With the continuous increase in radiotherapy patient-specific data from multimodality imaging and biotechnology molecular sources, knowledge-based response-adapted radiotherapy (KBR-ART) is emerging as a vital area for radiation oncology personalized ...
Huan-Hsin Tseng, Yi Luo, Randall K. Ten Haken, Issam El Naqa   +3 more
doaj   +1 more source

Impact of on-trial IGRT quality assurance in an international adaptive radiotherapy trial for participants with bladder cancer.

BACKGROUND AND PURPOSE: Radiotherapy trial quality assurance (RT QA) is crucial for ensuring the safe and reliable delivery of radiotherapy trials, and minimizing inter-institutional variations.
Webster, A, Hall, E, McNair, H, Griffin, C, Miles, E, Gribble, H, Hansen, VN, Lewis, R, Huddart, R, Francis, M, Hafeez, S, RAIDER Trial Management Group,   +11 more
core   +1 more source

Adaptive radiotherapy for invasive bladder cancer: a feasibility study

, 2006
To evaluate the feasibility of adaptive radiotherapy (ART) in combination with a partial bladder irradiation. Twenty-one patients with solitary T1-T4 N0M0 bladder cancer were treated to the bladder tumor + 2 cm margin planning target volume (PTV(CONV ...
Hulshof, Maarten, Lebesque, Joos, Lotz, Heidi, Remeijer, Peter, van Tienhoven, Geertjan, Moonen, Luc, Pos, Floris J.   +6 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Postoperative irradiation for squamous cell carcinoma of head and neck: Retrospective comparison of accelerated radiochemotherapy and standard radiotherapy [PDF]

, 2000
Background: Comparison of accelerated radiochemotherapy (aRCT) and standard radiotherapy (sRT) in postoperative treatment after macroscopically complete resection of squamous cell cancers of head and neck.
Kiszel, Z., Busch, M., Kastenbauer, E., Panzer, Monika, Dühmke, Eckhart, Klaiber, R., Jund, R., Schaffer, Moshe, Winter, W.   +8 more
core   +2 more sources

Evaluation of delivered dose for a clinical daily adaptive plan selection strategy for bladder cancer radiotherapy

, 2015
To account for variable bladder size during bladder cancer radiotherapy, a daily plan selection strategy was implemented. The aim of this study was to calculate the actually delivered dose using an adaptive strategy, compared to a non-adaptive approach ...
de Jong, Rianne, Lutkenhaus, Lotte J., Visser, Jorrit, Hulshof, Maarten C. C. M., Bel, Arjan   +4 more
core   +1 more source

Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer

, 2020
Primary vaginal cancer is a rare cancer and clinical evidence to support recommendations on its optimal management is insufficient. Because primary vaginal cancer resembles cervical cancer in many aspects, treatment strategies are mainly adopted from ...
Nesvacil, Nicole, Nout, Remi, Milosevic, Michael, Westerveld, H; id_orcid, Fokdal, L, Chargari, C, Milosevic, M, Nesvacil, N, Schmid, MP, Fokdal, Lars, Westerveld, H, Mahantshetty, Umesh M., Mahantshetty, UM, Westerveld, Henrike, Chargari, Cyrus, Schmid, Maximilian P., Nout, Remi A.   +16 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source