Results 81 to 90 of about 1,387,215 (249)

Predicting the need for adaptive radiotherapy in head and neck cancer [PDF]

, 2015
Background and purpose: Adaptive radiotherapy (ART) can account for the dosimetric impact of anatomical change in head and neck cancer patients; however it can be resource intensive.
Oestreich, Kimberley, Mengersen, Kerrie, Poulsen, Michael, Owen, Rebecca, Porceddu, Sandro, Lin, Charles, Houghton, Whitney, Harden, Fiona, Harris, Selina, Brown, Elizabeth   +9 more
core   +1 more source

Feasibility of Conebeam CT-based online adaptive radiotherapy for neoadjuvant treatment of rectal cancer

, 2021
Background Online adaptive radiotherapy has the potential to reduce toxicity for patients treated for rectal cancer because smaller planning target volumes (PTV) margins around the entire clinical target volume (CTV) are required.
van Wieringen, Niek, Arjan Bel, Jorrit Visser, Jan Wiersma, de Jong, Rianne, Wiersma, Jan, Rianne de Jong, Niek van Wieringen, Geijsen, Debby, Visser, Jorrit, Debby Geijsen, Bel, Arjan   +11 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evaluating CBCT-Guided Adaptive Radiotherapy for Pancreatic Cancer Using Synthetic CBCT Data

Current Oncology
Ethos adaptive radiotherapy is employed frequently in the pelvis to improve treatment accuracy by adapting to daily anatomical changes. The use of this CBCT-guided platform for abdominal treatments is made challenging by motion-related image artifacts ...
Sven Olberg, Leah L. Thompson, Hannah J. Roberts, Jennifer Y. Wo, Theodore S. Hong, John Wolfgang, Clemens Grassberger, Jennifer Pursley   +7 more
doaj   +1 more source

Towards rapid and efficient simulation-free radiotherapy: MR guided adaptive prostate radiotherapy on the MR-Linac using diagnostic MRI reference planning.

BACKGROUND AND PURPOSE: Simulation-free radiotherapy offers improved efficiency for adaptive treatments. This planning study presents a simulation-free pre-treatment workflow for prostate cancer online adaptive radiotherapy on a MR-Linac.
Oelfke, U, Chick, J, Alexander, S, Nill, S, Dunlop, A, Herbert, T, Cooper, S, Predescu, N, Casey, F, Lőrincz-Molnár, S-B, Tree, A   +10 more
core   +1 more source

Adaptive margin radiotherapy for patients with prostate carcinoma: what's the benefit?

, 2012
With daily portal images and repeated CT scans from 20 patients with gold markers (GM) an adaptive margin radiotherapy strategy (AMRT) was simulated and compared to traditional bony anatomy (BA) and standard GM verification protocols.
Koning, Caro C E, Haverkort, Marie A. D., Pieters, Bradley R, Koning, Caro C. E., Haverkort, Marie A D, van de Kamer, Jeroen B., van Tienhoven, Geertjan, van de Kamer, Jeroen B, van Herk, Marcel, Pieters, Bradley R., Van Herk, Marcel; id_orcid   +10 more
core   +1 more source

The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator. [PDF]

, 2018
PURPOSE: Until now, real-time image guided adaptive radiation therapy (IGART) has been the domain of dedicated cancer radiotherapy systems. The purpose of this study was to clinically implement and investigate real-time IGART using a standard linear ...
Eade, T, Martin, J, Regina Bromley, Ricky O'Brien, Jeremy T. Booth, Nguyen, DT, Bell, L, Booth, JT, Per Rugaard Poulsen, Jarad Martin, Paul J. Keall, Emily Hewson, Hewson, E, Keall, P, Poulsen, PR, Keall, PJ, Bromley, R, Kneebone, A, O'Brien, R, Linda Bell, Andrew Kneebone, Thomas Eade, Caillet, V, Doan Trang Nguyen, Vincent Caillet   +24 more
core   +1 more source