Results 81 to 90 of about 83,753 (298)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A method for generating large datasets of organ geometries for radiotherapy treatment planning studies

Radiology and Oncology, 2014
Background. With the rapidly increasing application of adaptive radiotherapy, large datasets of organ geometries based on the patient’s anatomy are desired to support clinical application or research work, such as image segmentation, re-planning, and ...
Hu Nan, Cerviño Laura, Segars Paul, Lewis John, Shan Jinlu, Jiang Steve, Zheng Xiaolin, Wang Ge   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The role of radiotherapy planning images in monitoring malnutrition and predicting prognosis in head and neck cancer patients: a pilot study

Radiation Oncology
Background Adaptive treatment planning can be made in radiotherapy of head and neck cancer patients for reasons such as changes in tumor volume or weight loss.
Beste M. Atasoy, Birsen Demirel, Feyza Nur Ekşi Özdaş, Bennur Devran, Zehra Nur Kılıç, Dilek Gül   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Salivary Function and Quality of Life Following Adaptive Intensity-Modulated Radiotherapy for Locally Advanced Head and Neck Cancer [PDF]

Research in Oncology
Background: Intensity-modulated radiotherapy (IMRT) is the standard treatment for locally advanced head and neck cancer (LAHNC). However, the potential role of adaptive radiotherapy in preserving salivary function and enhancing quality of life (QoL ...
Wael El-Sheshtawy, Mostafa Mostafa
doaj   +1 more source

Image guidance in radiation therapy for better cure of cancer

Molecular Oncology, 2020
The key goal and main challenge of radiation therapy is the elimination of tumors without any concurring damages of the surrounding healthy tissues and organs.
Vincent Grégoire, Matthias Guckenberger, Karin Haustermans, Jan J. W. Lagendijk, Cynthia Ménard, Richard Pötter, Ben J. Slotman, Kari Tanderup, Daniela Thorwarth, Marcel vanHerk, Daniel Zips   +10 more
doaj   +1 more source

Development of a GPU-based Monte Carlo dose calculation code for coupled electron-photon transport

, 2010
Monte Carlo simulation is the most accurate method for absorbed dose calculations in radiotherapy. Its efficiency still requires improvement for routine clinical applications, especially for online adaptive radiotherapy.
Amitava Majumdar, Bielajew A F Hirayama H Nelson W R Rogers D W O, Briesmeister J F, Dongju Choi, Gu X, Gu X, Jacques R Taylor R Wong J McNutt T, Josep Sempau, Lensch H Strzodka R, Li J S, Li M, Ma C M, Men C, Nelson W R Hirayama H Rogers D W O, NVIDIA, Salvat F Fernández-Varea J M Baró J Sempau J, Salvat F Fernández-Varea J M Sempau J, Sempau J, Sharp G C, Steve B Jiang, Woodcock E Murphy T Hemmings P Longworth S, Xu F, Xuejun Gu, Xun Jia, Yan G R   +24 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source